gene

RPL17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

11Outgoing

0Incoming

0Experiments

0Debates

Summary

RPL17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, binds. Associated with ankylosing spondylitis, breast cancer, migraine. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPL17
Full Name	Ribosomal Protein L17
Chromosome	18q21.1
Function	RPL17 encodes Ribosomal Protein L17 (also known as L23), a component of the large (60S) ribosomal subunit.
Primary Expression	AD brain [@hernandezortega2016] - RPL17 shows altered expression in AD temporal lobe - Global translation deficits in AD neurons correlate with cognit
UniProt ID	P18621
NCBI Gene ID	6169
GeneCards	RPL17
Human Protein Atlas	RPL17
Protein synthesis	Part of the peptidyl transferase center [@yoshikawa2018]
Ribosome assembly	Critical for proper 60S subunit formation
rRNA binding	Interacts with 28S rRNA
Translation termination	Contributes to release factor recognition
Associated Diseases	ankylosing spondylitis, migraine, osteoporosis
Interactions	YBX1
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPL17 — AlphaFold P18621 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPL17 — Ribosomal Protein L17

gene · 1726 words

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Pathway Diagram

graph TD
    RPL17["RPL17"]
    HCV["HCV"]
    RPL17 -->|"binds"| HCV
    YBX1["YBX1"]
    RPL17 -->|"interacts with"| YBX1
    STAT5b["STAT5b"]
    RPL17 -->|"binds"| STAT5b
    APOA1["APOA1"]
    RPL17 -->|"regulates"| APOA1
    intestinal_stem_cells["intestinal stem cells"]
    RPL17 -->|"participates in"| intestinal_stem_cells
    n_5_8S_rRNA["5.8S rRNA"]
    RPL17 -->|"regulates"| n_5_8S_rRNA
    breast_cancer{"breast cancer"}
    RPL17 -->|"regulates"| breast_cancer
    A_["Abeta"]
    RPL17 -->|"associated with"| A_
    ankylosing_spondylitis{"ankylosing spondylitis"}
    RPL17 -->|"associated with"| ankylosing_spondylitis
    osteoporosis{"osteoporosis"}
    RPL17 -->|"associated with"| osteoporosis
    migraine{"migraine"}
    RPL17 -->|"associated with"| migraine
    neurodegeneration["neurodegeneration"]
    RPL17 -->|"implicated in"| neurodegeneration
    style RPL17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
HCV	binds	entity	0.80
YBX1	interacts_with	protein	0.80
intestinal stem cells	participates_in	cell_type	0.80
5.8S rRNA	regulates	entity	0.80
breast cancer	regulates	disease	0.80
STAT5b	binds	protein	0.80
APOA1	regulates	gene	0.80
ankylosing spondylitis	associated_with	disease	0.70
osteoporosis	associated_with	disease	0.70
migraine	associated_with	disease	0.70
Aβ	associated_with	chemical	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPL17 in their description or question text

No additional research found