| Global prevalence | Approximately 12% of the general population, or about 1 billion people worldwide [@global1990]. |
| Gender distribution | Women are disproportionately affected, with a 3:1 female-to-male ratio, largely attributed to hormonal influences [@sex2023]. |
| Age of onset | Most commonly begins during adolescence, with peak prevalence in the 30-39 year age group [@age2021]. |
| Chronification | Approximately 2-3% of episodic migraine sufferers develop chronic migraine (≥15 headache days per month) annually [@chronic2024]. |
| Economic impact | Migraine results in significant productivity losses, estimated at $13-17 billion annually in the United States alone. |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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