gene

NRGN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRGN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

1Hypotheses

0Analyses

17Outgoing

19Incoming

0Experiments

0Debates

Summary

Page for NRGN Gene - Neurogranin

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🧬 Gene Info

Gene Symbol	NRGN
Full Name	Neurogranin
Aliases	Page for NRGN Gene
Chromosome	11q24.2
Function	Synaptic plasticity, CaM signaling
Primary Expression	Cerebral cortex, Hippocampus, Amygdala, Cerebellum
Molecular Weight	8.6 kDa
Amino Acids	78 aa
Exons	3
UniProt ID	P60761
NCBI Gene ID	4900
Ensembl ID	ENSG00000143545
OMIM	605532
GeneCards	NRGN
Human Protein Atlas	NRGN
Associated Diseases	Alzheimer's Disease, Intellectual Disability
Interactions	AND, BCL2, BNIP3L, LAMP1, LC3, MAP1LC3
SciDEX Hypotheses	Neurogranulin Predicts p-tau217 Reliability by Ide
KG Connections	36 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NRGN — AlphaFold P60761 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NRGN Gene - Neurogranin

gene · 1626 words

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Pathway Diagram

graph TD
    NRGN["NRGN"]
    Alzheimer{"Alzheimer"}
    NRGN -->|"expressed_in"| Alzheimer
    Als{"Als"}
    NRGN -->|"expressed_in"| Als
    ALS{"ALS"}
    NRGN -->|"expressed_in"| ALS
    MEF2C["MEF2C"]
    NRGN -->|"inhibits"| MEF2C
    ALZHEIMER["ALZHEIMER"]
    NRGN -->|"expressed_in"| ALZHEIMER
    ALZHEIMER -->|"expressed_in"| NRGN
    SH3GL2["SH3GL2"]
    SH3GL2 -->|"inhibits"| NRGN
    GENES["GENES"]
    GENES -->|"expressed_in"| NRGN
    MEF2C -->|"inhibits"| NRGN
    AND["AND"]
    AND -->|"inhibits"| NRGN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed_in"| NRGN
    Covid{"Covid"}
    NRGN -->|"inhibits"| Covid
    neurodegeneration["neurodegeneration"]
    NRGN -->|"implicated_in"| neurodegeneration

Outgoing (17)

Target	Relation	Type	Str
Synaptic Dysfunction	biomarker_for	mechanism	0.85
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
SH3GL2	inhibits	gene	0.60
MEF2C	inhibits	gene	0.60
S100B	biomarker_for	gene	0.60
neurodegeneration	biomarker_for	disease	0.60
ALZHEIMER	expressed_in	gene	0.60
Alzheimer's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
PINK1	phosphorylates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
TFEB	activates	gene	0.60
Covid	inhibits	disease	0.50

Incoming (19)

Source	Relation	Type	Str
ALS	biomarker_for	gene	0.60
FGF	biomarker_for	gene	0.60
MAP1LC3	activates	gene	0.60
MEF2C	inhibits	gene	0.60
C3	biomarker_for	gene	0.60
GDNF	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
SH3GL2	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
MAPT	phosphorylates	gene	0.60
NEFL	phosphorylates	gene	0.60
BCL2	activates	gene	0.60
BNIP3L	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MAPT	activates	gene	0.60
NEFL	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neurogranulin Predicts p-tau217 Reliability by Identifying P	0.498	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRGN in their description or question text

No additional research found