gene

NGN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NGN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

23Outgoing

6Incoming

0Experiments

0Debates

Summary

NGN2 encodes a bHLH transcription factor that acts as a master regulator of excitatory neuronal fate determination. Essential for cortical development, neuronal differentiation, and neurogenesis. Linked to neurodevelopmental disorders and neurodegeneration.

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🧬 Gene Info

Gene Symbol	NGN2
Full Name	Neurogenin-2
Chromosome	4q21.1
Function	regulator of excitatory neuronal fate determination
Molecular Weight	34.7 kDa
Amino Acids	199 aa
Exons	2
Pathways	Notch signaling
UniProt ID	Q9HSY5
NCBI Gene ID	63973
Ensembl ID	ENSG00000174348
OMIM	607574
GeneCards	NGN2
Human Protein Atlas	NGN2
1995	Neurogenin family identified
Associated Diseases	ALS
Interactions	DISC1, GENES, NGN1
KG Connections	29 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NGN2 — AlphaFold Q9HSY5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NGN2 (Neurogenin-2)

gene · 2058 words

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NGN2 Protein

protein · 552 words

→

Pathway Diagram

graph TD
    NGN2["NGN2"]
    Schizophrenia{"Schizophrenia"}
    NGN2 -->|"activates"| Schizophrenia
    Aging{"Aging"}
    NGN2 -->|"activates"| Aging
    Depression{"Depression"}
    NGN2 -->|"activates"| Depression
    Bipolar{"Bipolar"}
    NGN2 -->|"activates"| Bipolar
    Ms{"Ms"}
    NGN2 -->|"activates"| Ms
    DISC1["DISC1"]
    NGN2 -->|"activates"| DISC1
    ASCL1["ASCL1"]
    NGN2 -->|"associated with"| ASCL1
    DLX2["DLX2"]
    NGN2 -->|"associated with"| DLX2
    neurodegeneration["neurodegeneration"]
    NGN2 -->|"implicated in"| neurodegeneration
    style NGN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
Schizophrenia	activates	disease	0.65
Aging	activates	disease	0.65
Depression	activates	disease	0.65
Bipolar	activates	disease	0.65
Ms	activates	disease	0.65
DISC1	activates	gene	0.60
ASCL1	associated_with	gene	0.60
DLX2	associated_with	gene	0.60
AND	regulates	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.60
NLGN1	regulates	gene	0.60
DCC	regulates	gene	0.60
NGN1	regulates	gene	0.60
App	therapeutic_target	protein	0.60
stem cells	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Cortex	regulates	brain_region	0.50
NEURONS	associated_with	concept	0.50

Incoming (6)

Source	Relation	Type	Str
DCC	regulates	gene	0.60
GENES	activates	gene	0.60
NGN1	regulates	gene	0.60
MEF2C	regulates	gene	0.60
EPHA5	regulates	gene	0.50
NGN1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NGN2 in their description or question text

No additional research found