gene 1,929 words KG: MEF2C
Contents

MEF2C Gene

🧬 Gene Info
Gene SymbolMEF2C
Full NameMyocyte Enhancer Factor 2C
Chromosome5q14.1
Protein TypeTranscription Factor
Functionis a calcium-dependent transcription factor belonging to the MADS (MCM1, Agamous, Deficiens, serum response factor) box family of MEF2 proteins.
Molecular Weight50 kDa
Exons15
PathwaysEffect on MEF2C
UniProt IDQ06413 (MEF2C)
NCBI Gene ID4208
Ensembl IDENSG00000081189
OMIM600662
GeneCardsMEF2C
Human Protein AtlasMEF2C
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compoundsrapamycin
InteractionsABCA7, ADORA1, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
SciDEX HypothesesMEF2C-Dependent Synaptic Gene Regulation
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70

Related Analyses (2)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Activity-dependent PGC-1α transcriptional program analysis
exploratory · proposed · Score: 0.80

See Also (9)

ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
ADORA1 Gene
gene · KG edge: activates
BIN1 — Bridging Integrator 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MEF2C activates NF2
CXCL12 associated_with MEF2C
FOXM1 causes MEF2C
IL6 associated_with MEF2C
NR1H3 causes MEF2C
RELB causes MEF2C
PLD3 associated_with MEF2C
ABCA7 associated_with MEF2C
SORL1 associated_with MEF2C
PICALM associated_with MEF2C

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