gene 734 words KG: MAOB
Contents

MAOB Gene

🧬 Gene Info
Gene SymbolMAOB
Full NameMonoamine Oxidase B
ChromosomeXp11.23
Protein FamilyMonoamine oxidase family
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionplatelets and in the mitochondrial outer membrane of serotonergic and dopaminergic neurons
Molecular Weight58.7 kDa
Pathwaysautophagy pathway
UniProt IDP50395
NCBI Gene ID4129
Ensembl IDENSG00000105707
OMIM309860
GeneCardsMAOB
Human Protein AtlasMAOB
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Anxiety, Dementia
InteractionsAKT1, APP, BCL2, CASP3, GENES, GSK3B
KG Connections157 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (13)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAOB associated_with GABRA1
MAOB associated_with CHAT
MAOB associated_with CYP2D6
MAOB associated_with APOE
MAOB associated_with HMGCR
MAOB associated_with OPRM1
MAOB associated_with SLC30A8
MAOB associated_with COMT
MAOB associated_with NBEA
MAOB associated_with HTR2C

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