gene

TRKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

1Hypotheses

0Analyses

50Outgoing

25Incoming

0Experiments

0Debates

Summary

Page for TRKA Gene

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🧬 Gene Info

Gene Symbol	TRKA
Chromosome	1q23.1
Protein Family	Trk family (TrkA, TrkB, TrkC)
Protein Type	Receptor
Function	is a high-affinity receptor tyrosine kinase for nerve growth factor (NGF), encoded by the NTRK1 gene on chromosome 1q21-22.
Primary Expression	basal forebrain cholinergic neurons (BFCNs), which are the primary source of acetylcholine to the hippocampus and neocortex
Subcellular Localization	</th><td>Plasma membrane, endosomes, retrograde signaling endosomes</td></tr>
Molecular Weight	140 kDa
Amino Acids	796 aa
Exons	17
Pathways	PI3K
GeneCards	TRKA
Human Protein Atlas	TRKA
ATP-binding site	Critical for catalytic activity and drug targeting
Tyrosine autophosphorylation sites	Tyr490, Tyr670, Tyr674, Tyr675 (major autophosphorylation sites)
Associated Diseases	Alzheimer, Alzheimer'S Disease, disease, Pain
Interactions	Actin, AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	118 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TrkA Protein — Tropomyosin Receptor Kinase A

protein · 1514 words

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TRKA Gene

gene · 1035 words

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Pathway Diagram

graph TD
    TRKA["TRKA"]
    Alzheimer["Alzheimer"]
    TRKA -->|"associated with"| Alzheimer
    Alzheimer["Alzheimer"]
    TRKA -->|"inhibits"| Alzheimer
    Als["Als"]
    TRKA -->|"inhibits"| Als
    Aging["Aging"]
    TRKA -->|"inhibits"| Aging
    Alzheimer["Alzheimer"]
    TRKA -->|"therapeutic target"| Alzheimer
    ALS["ALS"]
    TRKA -->|"inhibits"| ALS
    NRP1["NRP1"]
    TRKA -->|"interacts with"| NRP1
    NGF["NGF"]
    TRKA -->|"interacts with"| NGF
    GAIN["GAIN"]
    TRKA -->|"inhibits"| GAIN
    AXON["AXON"]
    TRKA -->|"regulates"| AXON
    NEURON["NEURON"]
    TRKA -->|"regulates"| NEURON
    AND["AND"]
    TRKA -->|"regulates"| AND
    CASP3["CASP3"]
    TRKA -->|"regulates"| CASP3
    ERK["ERK"]
    TRKA -->|"phosphorylates"| ERK
    Neuron["Neuron"]
    TRKA -->|"associated with"| Neuron
    NGF["NGF"]
    TRKA -->|"activates"| NGF
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"inhibits"| ALZHEIMER
    MAPK["MAPK"]
    TRKA -->|"inhibits"| MAPK
    AGING["AGING"]
    TRKA -->|"inhibits"| AGING
    Mapk["Mapk"]
    TRKA -->|"inhibits"| Mapk
    Neuron["Neuron"]
    TRKA -->|"inhibits"| Neuron
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"therapeutic target"| ALZHEIMER
    NGF["NGF"]
    TRKA -->|"therapeutic target"| NGF
    MAO["MAO"]
    TRKA -->|"associated with"| MAO
    APOPTOSIS["APOPTOSIS"]
    TRKA -->|"associated with"| APOPTOSIS
    ALZHEIMER["ALZHEIMER"]
    TRKA -->|"associated with"| ALZHEIMER
    NTRK2["NTRK2"]
    TRKA -->|"associated with"| NTRK2
    BDNF["BDNF"]
    TRKA -->|"interacts with"| BDNF
    TRKC["TRKC"]
    TRKA -->|"interacts with"| TRKC
    TRKB["TRKB"]
    TRKA -->|"interacts with"| TRKB

Outgoing (93)

Target	Relation	Type	Str
Opioid	inhibits	disease	0.65
Chronic Pain	inhibits	disease	0.65
Als	activates	disease	0.65
Neuropathy	transports	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
AGING	inhibits	gene	0.60
Mapk	inhibits	pathway	0.60
Neuron	inhibits	cell_type	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MAO	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
Akt	inhibits	protein	0.60
TRKB	interacts_with	gene	0.60
App	therapeutic_target	protein	0.60
TRKC	interacts_with	gene	0.60
Neuron	associated_with	cell_type	0.60
ALZHEIMER	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
NGF	activates	gene	0.60
NGF	therapeutic_target	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
RET	regulates	gene	0.60
MAP1B	transports	gene	0.60
TAU	transports	gene	0.60
DYNEIN	transports	gene	0.60
TRKB	regulates	gene	0.60
TRKC	regulates	gene	0.60
Schwann Cell	transports	cell_type	0.60
Dynein	transports	protein	0.60
CRY2	activates	gene	0.60
ERK	phosphorylates	protein	0.60
AND	interacts_with	gene	0.60
Long-Term Potentiation	associated_with	pathway	0.60
AMYLOID	therapeutic_target	gene	0.60
Myosin	associated_with	protein	0.60
Aβ	regulates	protein	0.60
Ngf	contributes_to	protein	0.60
Ngf	activates	protein	0.60
Myosin	therapeutic_target	protein	0.60
Ngf	therapeutic_target	protein	0.60
Ngf	interacts_with	protein	0.60

Incoming (25)

Source	Relation	Type	Str
NGF	binds_to	protein	0.60
NGF	contributes_to	gene	0.60
APP	interacts_with	gene	0.60
TAU	regulates	gene	0.60
AKT	inhibits	gene	0.60
NGF	activates	gene	0.60
NGF	interacts_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	inhibits	gene	0.60
CREB	activates	gene	0.60
ERBB2	activates	gene	0.60
IFN	activates	gene	0.60
NGF	therapeutic_target	gene	0.60
IRF3	activates	gene	0.60
PERK	activates	gene	0.60
RORA	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MYELIN	transports	gene	0.60
NEURON	activates	gene	0.60
NTRK2	co_expressed_with	gene	0.50
TRKB	interacts_with	gene	0.50
TRKC	interacts_with	gene	0.50
BDNF	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Basal forebrain NGF/TrkA trophic failure is an upstream trig	0.610	neurodegeneration	What determines the temporal sequence of

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRKA in their description or question text

No additional research found