protein 621 words KG: MAOAPROTEIN
Contents

MAO-A (Monoamine Oxidase A) Protein

🔬 Protein Info
Gene SymbolMAO
Full NameA (Monoamine Oxidase A) Protein
PathwaysMitochondrial Function, Epigenetic, Proteasome, Oxidative Stress, Ubiquitin-Proteasome
GeneCardsMAO
Human Protein AtlasMAO
MAO-BComplementary monoamine oxidase isoform with distinct substrate preferences
Monoamine NeurotransmittersPrimary substrates including serotonin, dopamine, and norepinephrine
Mitochondrial DysfunctionDownstream consequence and contributing factor to MAO-A-mediated pathology
Oxidative StressPrimary pathological mechanism linking MAO-A dysregulation to neurodegeneration
Parkinsonian DisordersPrimary clinical conditions associated with MAO-A dysregulation
Associated DiseasesAlzheimer, Alzheimer's disease, Ms, neurodegeneration, Parkinson
Known Drugs/Compoundslevodopa, riluzole
InteractionsABCA1, ABCG1, ACTB, Actin, AD, AHR
KG Connections262 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (4)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Combination Therapy Sequencing in Parkinson's Disease
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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