gene 699 words KG: MAOA
Contents

MAOA Gene

🧬 Gene Info
Gene SymbolMAOA
Full NameMonoamine Oxidase A
ChromosomeXp11.23
Protein FamilyMonoamine oxidase family
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight59.7 kDa
PathwaysNeurotoxicity
UniProt ID[P21397](https://www.uniprot.org/uniprot/P21397)
NCBI Gene ID4128
Ensembl IDENSG00000189221
OMIM309850
GeneCardsMAOA
Human Protein AtlasMAOA
NeurotransmittersSerotonin (5-HT), norepinephrine, dopamine
Associated Diseasescancer, Inflammation, Neurodegeneration, Neuroinflammation
InteractionsADRA2A, AGING, AKT, AND, APP, BCL2
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
GFAP (Redirect)
redirect · KG edge: therapeutic_target
IL6 (Redirect)
redirect · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

IL6 activates MAOA
RANKL activates MAOA
SHH activates MAOA
MAOA interacts_with APP
MAOA therapeutic_target BDNF
MAOA therapeutic_target GFAP
MAOA therapeutic_target BAX
MAOA interacts_with IL1B
MAOA interacts_with GSK3B
MAOA therapeutic_target IL1A

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