gene

RAB11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RAB11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB11A
Full Name	Ras-Related Protein Rab-11A
Aliases	Page for RAB11A
Function	RAB11A functions in the recycling endosome compartment
Molecular Weight	24 kDa
Amino Acids	216 aa
UniProt ID	RAB11A
Ensembl ID	ENSG00000103740
GeneCards	RAB11A
Human Protein Atlas	RAB11A
Endosomal sorting	RAB11A sorts synaptic vesicle membrane proteins from early endosomes to recycling endosomes
Synaptic vesicle reformation	RAB11A traffics recycling vesicles back to the presynaptic terminal where they are reloaded with neurotransmitter
Synaptic plasticity	RAB11A-dependent recycling supports activity-dependent changes in synaptic strength [@bartz2020]
Associated Diseases	Aging, Als, Ftd, Neurodegeneration
Interactions	Albumin, AND, APOE, C1Q, C1Q/C3, COMPLEMENT
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RAB11 — AlphaFold P62491 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB11["RAB11"]
    RAB11 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    RAB11 -->|"target for"| Aging["Aging"]
    RAB11 -->|"target for"| Ms["Ms"]
    RAB11 -->|"target for"| Als["Als"]
    RAB11 -->|"target for"| STX17["STX17"]
    RAB11 -->|"inhibits"| RAB5["RAB5"]
    RAB11 -->|"target for"| SNAP29["SNAP29"]
    RAB11 -->|"target for"| IGF2BP1["IGF2BP1"]
    RAB11 -->|"target for"| LONP1["LONP1"]
    ELAVL2["ELAVL2"] -->|"target for"| RAB11
    C1Q["C1Q"] -->|"inhibits"| RAB11
    MTOR["MTOR"] -->|"target for"| RAB11
    CLPP["CLPP"] -->|"target for"| RAB11
    TFR1["TFR1"] -->|"regulates"| RAB11
    PI3K["PI3K"] -->|"target for"| RAB11
    BDNF["BDNF"] -->|"target for"| RAB11
    METTL3["METTL3"] -->|"target for"| RAB11
    AUTOPHAGY["AUTOPHAGY"] -->|"target for"| RAB11
    SNAP29 -->|"target for"| RAB11

Outgoing (137)

Target	Relation	Type	Str
Als	encodes	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Als	contributes_to	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	encodes	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
Aging	encodes	disease	0.65
Ftd	therapeutic_target	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	contributes_to	disease	0.65
Tumor	regulates	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Mapk	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
COMPLEMENT	inhibits	gene	0.60
AGING	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Raf	regulates	protein	0.60
Tdp-43	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Akt	therapeutic_target	pathway	0.60
AND	expressed_in	gene	0.60
ENDOSOMES	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
AD RISK GENES	regulates	gene	0.60
ARF6	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Bdnf	expressed_in	protein	0.60
APOE	activates	gene	0.60
GBM	regulates	gene	0.60
WNT	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60

Incoming (101)

Source	Relation	Type	Str
GENES	regulates	gene	0.60
C1Q	inhibits	gene	0.60
MTOR	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
TFR1	regulates	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
SNAP29	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
RAB5	inhibits	gene	0.60
STX17	therapeutic_target	gene	0.60
IGF2BP1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
METTL3	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
ENDOSOME	activates	gene	0.60
LYSOSOME	activates	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
FUS	associated_with	gene	0.60
C1Q/C3	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
MTOR	associated_with	gene	0.60
ELAVL2	encodes	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60
TDP-43	encodes	gene	0.60
STX17	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	encodes	gene	0.60
IGF2BP1	encodes	gene	0.60
TRKB	expressed_in	gene	0.60
AGING	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
ENDOSOMES	expressed_in	gene	0.60
SREBP2	regulates	gene	0.60
RNA	regulates	gene	0.60
GLUT1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity