| Gene Symbol | SLC39A4 |
| Full Name | Solute Carrier Family 39 Member 4 |
| Chromosome | 8q21.3 |
| Protein Type | Transporter |
| Function | is an essential trace element fundamental to numerous biological processes, including enzyme function, gene expression, immune response, and neurological signaling. |
| Primary Expression | pancreatic acinar cells, contributing to zinc secretion in digestive fluids |
| Amino Acids | 647 aa |
| UniProt ID | [Q9NPF7](https://www.uniprot.org/uniprot/Q9NPF7) |
| Ensembl ID | ENSG00000147894 |
| GeneCards | SLC39A4 |
| Human Protein Atlas | SLC39A4 |
| Eight transmembrane domains | The protein contains eight predicted transmembrane helices that span the plasma membrane, creating a channel through which zinc ions are transported[@moynie2019]. |
| N-linked glycosylation sites | The extracellular loops contain asparagine-linked glycosylation motifs that are important for proper protein folding, trafficking to the plasma membrane, and stability[@valenzano2011]. |
| Dimetric arrangement | Functional ZIP4 likely operates as a homodimer, with each monomer capable of forming an independent transport pathway. This dimeric structure is conserved among ZIP family members. |
| Intestine | Highest expression in the apical membrane of enterocytes in the small intestine, where it mediates dietary zinc absorption[@wang2004]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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