concept

CISPLATIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CISPLATIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

42Outgoing

27Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CISPLATIN
Key Genes/Proteins	AKT, BAX, CLU, HNRNPA1
Related Diseases	APOPTOSIS, BREAST CANCER, CANCER, DRUG RESISTANCE, FERROPTOSIS

Pathway Diagram

graph TD
    CISPLATIN["CISPLATIN"]
    CISPLATIN -->|"treats"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    CISPLATIN -->|"causes"| Chemotherapy_Induced_Periphera["Chemotherapy-Induced Peripheral Neuropathy"]
    CISPLATIN -->|"causes"| acute_kidney_injury["acute kidney injury"]
    CISPLATIN -->|"causes"| Mitochondrial_Damage["Mitochondrial Damage"]
    CISPLATIN -->|"binds"| DNA["DNA"]
    CISPLATIN -->|"activates"| mitophagy["mitophagy"]
    CISPLATIN -->|"activates"| PACLITAXEL["PACLITAXEL"]
    CISPLATIN -->|"activates"| ROS["ROS"]
    CANCER["CANCER"] -->|"activates"| CISPLATIN
    BAX["BAX"] -->|"interacts"| CISPLATIN
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| CISPLATIN
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| CISPLATIN

Outgoing (42)

Target	Relation	Type	Str
Triple-Negative Breast Cancer	treats	disease	0.95
acute kidney injury	causes	disease	0.95
Chemotherapy-Induced Peripheral Neuropathy	causes	disease	0.95
Mitochondrial Damage	causes	phenotype	0.90
BREAST CANCER	treats	disease	0.65
LUNG CANCER	inhibits	disease	0.65
mitophagy	activates	pathway	0.56
AKT	associated_with	gene	0.50
PACLITAXEL	activates	drug	0.50
PACLITAXEL	associated_with	drug	0.45
ISCHEMIA	associated_with	disease	0.45
MITOPHAGY	associated_with	phenotype	0.45
CLU	associated_with	gene	0.45
BAX	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
SOD1	associated_with	gene	0.45
DOCETAXEL	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
OXALIPLATIN	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
MITOCHONDRIA	associated_with	phenotype	0.45
FIBROBLASTS	associated_with	cell_type	0.45
FERROPTOSIS	associated_with	phenotype	0.45
LUNG CANCER	associated_with	disease	0.45
HNRNPA1	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
ROS	associated_with	phenotype	0.45
LUNG CANCER	activates	disease	0.35
FERROPTOSIS	activates	process	0.35
LONG NON-CODING RNA	activates	process	0.35
LUNG CANCER	therapeutic_target	disease	0.35
LONG NON-CODING RNA	regulates	process	0.35
PACLITAXEL	protects_against	drug	0.35
MITOPHAGY	interacts_with	process	0.35
NEUROPATHY	activates	disease	0.35
ROS	activates	protein	0.35
NF-KB	activates	gene	0.35
SOD1	activates	gene	0.35
FIBROBLASTS	activates	cell_type	0.35
ROS	inhibits	protein	0.35
LC3	interacts_with	gene	0.35
ISCHEMIA	activates	disease	0.35

Incoming (27)

Source	Relation	Type	Str
Dicyanoargentate(I) complexes	associated_with	compound	0.70
TUMOR MICROENVIRONMENT	activates	phenotype	0.65
CARFILZOMIB	targets	drug	0.65
AKT	inhibits	gene	0.65
NFkB	associated_with	pathway	0.56
TUMOR GROWTH	associated_with	phenotype	0.50
DRUG RESISTANCE	associated_with	phenotype	0.50
BORTEZOMIB	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
BREAST CANCER	associated_with	disease	0.45
FIBROBLASTS	associated_with	cell_type	0.45
LUNG CANCER	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
PACLITAXEL	associated_with	drug	0.45
OXALIPLATIN	associated_with	drug	0.45
APOPTOSIS	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.45
5-FLUOROURACIL	associated_with	drug	0.45
BAX	associated_with	gene	0.45
BREAST CANCER	activates	disease	0.35
BREAST CANCER	therapeutic_target	disease	0.35
APOPTOSIS	inhibits	process	0.35
BAX	interacts_with	gene	0.35
CANCER	inhibits	disease	0.35
CANCER	activates	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CISPLATIN in their description or question text

No additional research found