gene

DUSP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

14Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for DUSP8 Gene

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🧬 Gene Info

Gene Symbol	Dual Specificity Phosphatase 8
Chromosome	22q12.2
Protein Type	Phosphatase
Function	DUSP8 encodes a dual-specificity phosphatase that belongs to the MAPK phosphatase (MKP) family.
Amino Acids	170 aa
Pathways	MAPK
UniProt ID	Q8WUA5
NCBI Gene ID	1853
Ensembl ID	ENSG00000134548
OMIM	607769
JNK (c-Jun N-terminal Kinase)	Mediates stress-induced apoptosis in neurons
p38 MAPK	Regulates inflammatory responses and neuronal death pathways
Brain	High expression in cortex, hippocampus, basal ganglia
Cerebral Cortex	Both pyramidal neurons and interneurons
Hippocampus	CA1-CA3 regions and dentate gyrus
Associated Diseases	Breast Cancer, Colorectal Cancer, Diabetic Kidney Disease, Trastuzumab Resistance
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DUSP8 — AlphaFold Q8WUA5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP8 Gene

gene · 966 words

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Pathway Diagram

graph TD
    DUSP8["DUSP8"]
    Pur("Pur-alpha")
    DUSP8 -->|"binds"| Pur
    IL_9["IL-9"]
    DUSP8 -->|"upregulates"| IL_9
    Th9_Cells["Th9 Cells"]
    DUSP8 -->|"associated_with"| Th9_Cells
    Glioblastoma{"Glioblastoma"}
    DUSP8 -->|"regulates"| Glioblastoma
    MAPK_Pathway(["MAPK Pathway"])
    DUSP8 -->|"regulates"| MAPK_Pathway
    Trastuzumab_Resistance["Trastuzumab Resistance"]
    DUSP8 -->|"associated_with"| Trastuzumab_Resistance
    p38("p38")
    DUSP8 -->|"associated_with"| p38
    ERK("ERK")
    DUSP8 -->|"associated_with"| ERK
    JNK("JNK")
    DUSP8 -->|"associated_with"| JNK
    Allergic_Asthma{"Allergic Asthma"}
    DUSP8 -->|"exacerbates"| Allergic_Asthma
    Atopic_Dermatitis{"Atopic Dermatitis"}
    DUSP8 -->|"exacerbates"| Atopic_Dermatitis
    Colorectal_Cancer{"Colorectal Cancer"}
    DUSP8 -->|"implicated_in"| Colorectal_Cancer
    Diabetic_Kidney_Disease{"Diabetic Kidney Disease"}
    DUSP8 -->|"implicated_in"| Diabetic_Kidney_Disease
    Breast_Cancer{"Breast Cancer"}
    DUSP8 -->|"implicated_in"| Breast_Cancer
    neurodegeneration["neurodegeneration"]
    DUSP8 -->|"implicated_in"| neurodegeneration

Outgoing (14)

Target	Relation	Type	Str
IL-9	upregulates	gene	0.90
Th9 Cells	associated_with	cell_type	0.90
Pur-α	binds	protein	0.90
p38	associated_with	protein	0.80
JNK	associated_with	protein	0.80
Allergic Asthma	exacerbates	disease	0.80
Atopic Dermatitis	exacerbates	disease	0.80
MAPK Pathway	regulates	pathway	0.80
Trastuzumab Resistance	associated_with	phenotype	0.80
Glioblastoma	regulates	disease	0.80
ERK	associated_with	protein	0.80
Colorectal Cancer	implicated_in	disease	0.70
Breast Cancer	implicated_in	disease	0.70
Diabetic Kidney Disease	implicated_in	disease	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP8 in their description or question text

No additional research found