gene

P75NTR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P75NTR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

P75NTR is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with ALS, Als, Alzheimer. Connected to 105 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P75NTR
Chromosome	17q21.33
Protein Family	TNF receptor superfamily (TNFRSF16)
Protein Type	Receptor
Function	is a member of the tumor necrosis factor receptor superfamily that serves as a key modulator of neurotrophin signaling.
Subcellular Localization	</th><td>Cell membrane, endosomes, nucleus</td></tr> [@matsuda2010]
Molecular Weight	75 kDa
Amino Acids	427 aa
Exons	6
Pathways	NF-κB
GeneCards	P75NTR
Human Protein Atlas	P75NTR
Full-length p75NTR	The canonical receptor with intact intracellular domain
p75NTR-Δ	Truncated isoform lacking the death domain, acts as a dominant-negative
p75NTR-S	Short isoform with alternative C-terminus
Associated Diseases	Als, Alzheimer, Cancer, Depression, Glioblastoma
Interactions	AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	148 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

p75NTR Protein

protein · 1616 words

→

P75NTR Gene

gene · 1196 words

→

Pathway Diagram

graph TD
    P75NTR["P75NTR"]
    NEUROTROPHINS["NEUROTROPHINS"]
    P75NTR -->|"interacts with"| NEUROTROPHINS
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    P75NTR -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    Neurodegeneration{"Neurodegeneration"}
    P75NTR -->|"interacts with"| Neurodegeneration
    Als{"Als"}
    P75NTR -->|"interacts with"| Als
    Alzheimer{"Alzheimer"}
    P75NTR -->|"interacts with"| Alzheimer
    Parkinson{"Parkinson"}
    P75NTR -->|"interacts with"| Parkinson
    Huntington{"Huntington"}
    P75NTR -->|"interacts with"| Huntington
    Neuropathy{"Neuropathy"}
    P75NTR -->|"interacts with"| Neuropathy
    P75NTR -->|"inhibits"| Alzheimer
    P75NTR -->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    P75NTR -->|"inhibits"| Huntington
    P75NTR -->|"inhibits"| Neurodegeneration
    PROBDNF["PROBDNF"]
    PROBDNF -->|"activates"| P75NTR
    BAX["BAX"]
    BAX -->|"activates"| P75NTR
    PI3K["PI3K"]
    PI3K -->|"activates"| P75NTR
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| P75NTR
    AKT["AKT"]
    AKT -->|"activates"| P75NTR
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"interacts with"| P75NTR
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| P75NTR
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"interacts with"| P75NTR
    ALS["ALS"]
    ALS -->|"interacts with"| P75NTR
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| P75NTR
    PARKINSON["PARKINSON"]
    PARKINSON -->|"interacts with"| P75NTR
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"interacts with"| P75NTR
    style P75NTR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (102)

Target	Relation	Type	Str
NFkB	activates	pathway	0.80
JNK	activates	pathway	0.80
RhoA	activates	pathway	0.80
Rac-GTPase	activates	pathway	0.80
Als	associated_with	disease	0.75
NEUROTROPHINS	interacts_with	protein	0.72
Depression	implicated_in	disease	0.65
Als	regulates	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Glioblastoma	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Neuropathy	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Huntington	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Huntington	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuropathy	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Aging	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Neuropathy	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
App	expressed_in	protein	0.60
ALS	associated_with	disease	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60

Incoming (52)

Source	Relation	Type	Str
Neurotrophins	binds	protein	0.95
ABETA	upregulates	protein	0.80
PROBDNF	activates	protein	0.80
ADAM17	regulates	gene	0.80
PROBDNF	binds_to	protein	0.80
BDNF	binds	gene	0.80
PROBDNF	activates	protein	0.80
BDNF	activates	gene	0.80
TRKB	activates	gene	0.80
DEPRESSION	implicated_in	gene	0.60
MIRNAS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
EXERCISE	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ERK	associated_with	gene	0.60
NF-KB	associated_with	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
CANCER	activates	gene	0.60
MICRORNAS	associated_with	gene	0.60
BDNF	regulates	gene	0.60
PI3K	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
AKT	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
SNCA	expressed_in	gene	0.60
JNK	activates	gene	0.60
RAS	associated_with	gene	0.60
ALZHEIMER	implicated_in	gene	0.60
CANCER	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
GLIOBLASTOMA	implicated_in	gene	0.60
GENES	expressed_in	gene	0.60
BAX	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
BDNF	associated_with	gene	0.60
TRKB	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
PAP	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P75NTR in their description or question text

No additional research found