concept

N-ACETYLCYSTEINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about N-ACETYLCYSTEINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

1Hypotheses

0Analyses

50Outgoing

24Incoming

0Experiments

0Debates

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💡 Concept Info

Name	N-ACETYLCYSTEINE
Key Genes/Proteins	CDK5, CHRNA7, ERK, GPX4, GSH, HMOX1
Related Diseases	FERROPTOSIS, GLAUCOMA, GLIOSIS, HYPERTENSION

Pathway Diagram

graph TD
    N_ACETYLCYSTEINE["N-ACETYLCYSTEINE"]
    N_ACETYLCYSTEINE -->|"inhibits"| Ferroptosis["Ferroptosis"]
    N_ACETYLCYSTEINE -->|"inhibits"| ROS["ROS"]
    N_ACETYLCYSTEINE -->|"treats"| Herpes_Simplex_Keratitis["Herpes Simplex Keratitis"]
    N_ACETYLCYSTEINE -->|"inhibits"| Disulfidptosis["Disulfidptosis"]
    N_ACETYLCYSTEINE -->|"targets"| Oxidative_Stress["Oxidative Stress"]
    N_ACETYLCYSTEINE -->|"activates"| TNF["TNF"]
    JNK["JNK"] -->|"activates"| N_ACETYLCYSTEINE
    APOPTOSIS["APOPTOSIS"] -->|"activates"| N_ACETYLCYSTEINE
    MICRORNA_REGULATION["MICRORNA REGULATION"] -->|"target for"| N_ACETYLCYSTEINE
    ERK["ERK"] -->|"activates"| N_ACETYLCYSTEINE
    HYPERTENSION["HYPERTENSION"] -->|"activates"| N_ACETYLCYSTEINE
    MAPK["MAPK"] -->|"activates"| N_ACETYLCYSTEINE
    GLIOSIS["GLIOSIS"] -->|"activates"| N_ACETYLCYSTEINE
    AXON["AXON"] -->|"activates"| N_ACETYLCYSTEINE

Outgoing (50)

Target	Relation	Type	Str
Oxidative Stress	inhibits	process	0.90
Ferroptosis	inhibits	process	0.85
paracetamol	interacts_with	entity	0.85
Herpes Simplex Keratitis	treats	disease	0.82
Disulfidptosis	inhibits	process	0.80
Paracetamol Hepatoprotection	promotes	process	0.80
Oxidative Stress	targets	process	0.75
NEURODEGENERATION	protects_against	phenotype	0.70
FERROPTOSIS	targets	phenotype	0.65
CDK5	inhibits	gene	0.65
CDK5	activates	gene	0.65
CDK5	treats	gene	0.65
TFEB	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
HO-1	associated_with	gene	0.50
RIPK1	associated_with	gene	0.50
KEAP1	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
ROS	therapeutic_target	protein	0.50
GPX4	associated_with	gene	0.50
ROS	activates	protein	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
SORAFENIB	associated_with	drug	0.45
TNF	associated_with	gene	0.45
TAU	associated_with	protein	0.45
GLIOSIS	associated_with	phenotype	0.45
NAC	associated_with	drug	0.45
P38	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
PYROPTOSIS	associated_with	phenotype	0.45
DEFERIPRONE	associated_with	drug	0.45
JNK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
SULFORAPHANE	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
INFLAMMATION	associated_with	phenotype	0.45
NECROPTOSIS	associated_with	phenotype	0.45
DEFEROXAMINE	associated_with	drug	0.45
CDK5	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
TNF	inhibits	gene	0.35
SORAFENIB	inhibits	drug	0.35
NEUROINFLAMMATION	activates	process	0.35
NEURODEGENERATION	activates	process	0.35
P38	activates	gene	0.35
NUCLEUS ACCUMBENS	regulates	brain_region	0.35
TNF	activates	gene	0.35

Incoming (24)

Source	Relation	Type	Str
GPX4	activates	gene	0.70
JNK	activates	gene	0.50
APOPTOSIS	activates	process	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
MAPK	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
GLIOSIS	associated_with	phenotype	0.45
JNK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
DEFEROXAMINE	associated_with	drug	0.45
AUTOPHAGY	activates	process	0.35
AUTOPHAGY	associated_with	process	0.35
FERROPTOSIS	activates	process	0.35
CHRNA7	regulates	gene	0.35
CHRNA7	expressed_in	gene	0.35
ERK	activates	gene	0.35
HYPERTENSION	activates	disease	0.35
MAPK	activates	gene	0.35
GLIOSIS	activates	process	0.35
MICRORNA REGULATION	therapeutic_target	process	0.35
GLIOSIS	inhibits	process	0.35
GLAUCOMA	protects_against	disease	0.35
GLIOSIS	protects_against	process	0.35
GSH	activates	gene	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f	0.760	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning N-ACETYLCYSTEINE in their description or question text

No additional research found