concept

NAC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

3Hypotheses

0Analyses

16Outgoing

21Incoming

1Experiments

0Debates

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💡 Concept Info

Name	NAC
Key Genes/Proteins	ERK, JNK
Related Diseases	ANXIETY, DEPRESSION, Glaucoma, GLAUCOMA, GLIOSIS
Related Pathways	MAPK
Linked Hypotheses	2 hypotheses

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NAC["NAC"]
    NAC -->|"inhibits"| Ros["Ros"]
    NAC -.protects against.-> Rotenone["Rotenone"]
    NAC -->|"inhibits"| ROS["ROS"]
    NAC -.protects against.-> Neurodegeneration["Neurodegeneration"]
    NAC -->|"inhibits"| Peroxidation["Peroxidation"]
    NAC -->|"inhibits"| p38_MAPK["p38/MAPK"]
    NAC -->|"treats"| Glaucoma["Glaucoma"]
    NAC -->|"inhibits"| disulfidptosis["disulfidptosis"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| NAC
    APOPTOSIS["APOPTOSIS"] -->|"activates"| NAC
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| NAC
    TNF["TNF"] -->|"activates"| NAC
    ERK["ERK"] -->|"activates"| NAC
    JNK["JNK"] -->|"activates"| NAC

Outgoing (16)

Target	Relation	Type	Str
ROS	inhibits	process	0.90
Ros	inhibits	process	0.90
Rotenone	protects_against	compound	0.90
Neurodegeneration	protects_against	process	0.85
Peroxidation	inhibits	process	0.82
p38/MAPK	inhibits	pathway	0.80
Glaucoma	treats	disease	0.75
MAPK	inhibits	pathway	0.70
Glaucoma	treats	disease	0.70
disulfidptosis	inhibits	process	0.70
NEUROINFLAMMATION	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
NUCLEUS ACCUMBENS	associated_with	brain_region	0.45
P38	associated_with	gene	0.45
TNF	associated_with	gene	0.45
NEURODEGENERATION	associated_with	phenotype	0.45

Incoming (21)

Source	Relation	Type	Str
TNF	activates	gene	0.50
ERK	activates	gene	0.50
JNK	activates	gene	0.50
AUTOPHAGY	activates	process	0.50
APOPTOSIS	activates	process	0.50
FERROPTOSIS	activates	process	0.50
N-ACETYLCYSTEINE	associated_with	drug	0.45
APOPTOSIS	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
DEFEROXAMINE	associated_with	drug	0.45
FERROPTOSIS	associated_with	phenotype	0.45
ERK	associated_with	gene	0.45
JNK	associated_with	gene	0.45
HYPERTENSION	associated_with	disease	0.45
MAPK	associated_with	gene	0.45
MAPK PATHWAY	associated_with	pathway	0.45
GLIOSIS	associated_with	phenotype	0.45
GLAUCOMA	associated_with	disease	0.45
ANXIETY	associated_with	disease	0.45
ASTROCYTES	associated_with	cell_type	0.45
DEPRESSION	associated_with	disease	0.45

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f	0.760	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosi	0.530	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple	0.487	neurodegeneration	How do pathological stress granules in n

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NAC in their description or question text

No additional research found

NAC