| Gene Symbol | JNK3 |
| Aliases | MAPK10, c-Jun N-terminal Kinase 3 |
| Function | is a neuron-specific member of the MAPK family that plays critical roles in neuronal survival, stress responses, and synaptic plasticity. |
| Primary Expression | brain regions vulnerable to neurodegeneration: |
| Subcellular Localization | </strong></td><td>Cytoplasm, nucleus (upon activation)</td></tr> |
| Molecular Weight | 46 kDa |
| Amino Acids | 464 aa |
| Pathways | MAPK |
| Ensembl ID | ENSG00000109339 |
| GeneCards | JNK3 |
| Human Protein Atlas | JNK3 |
| JNK3α2 | Alternative splice variant |
| JNK3β | Truncated isoform |
| Kinase domain | Ser/Thr protein kinase domain (residues 47-362) |
| Activation loop | T221/Y223 phosphorylation sites required for activation |
| Associated Diseases | neurodegeneration |
| Interactions | AND, APOPTOSIS, ASTROCYTE, ASTROCYTES, FERROPTOSIS, GENES |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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