protein

CDK5R2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK5R2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

29Outgoing

23Incoming

0Experiments

0Debates

Summary

Page for CDK5R2 Protein

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🔬 Protein Info

Gene Symbol	CDK5R2
Full Name	Cyclin-Dependent Kinase 5 Regulatory Subunit 2
Chromosome	9q22.33
Function	is a neuron-specific gene that encodes a regulatory subunit of CDK5, a proline-directed serine/threonine kinase critical for neuronal function.
Primary Expression	Neuron-specific
Subcellular Localization	## Disease Associations
Molecular Weight	36 kDa
UniProt ID	Q16569
NCBI Gene ID	8941
Ensembl ID	ENSG00000100157
GeneCards	CDK5R2
Human Protein Atlas	CDK5R2
Neuron-specific activation	p39 expression is largely restricted to neurons, making CDK5 activity in the brain uniquely regulated by this activator
Alternative splicing	The CDK5R2 gene produces multiple isoforms with different tissue distributions and regulatory properties
Calcium-dependent activation	p39 cleavage by calpain produces p25, a hyperactive fragment similar to p35 cleavage in disease states
Associated Diseases	Inflammation
Interactions	FGF13, GRM5, ISG15, SCN2B, SCN8A, SLC17A7
KG Connections	52 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK5R2 — AlphaFold Q16569 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK5R2 Gene

gene · 795 words

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CDK5R2 Protein

protein · 1098 words

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Pathway Diagram

graph TD
    CDK5R2["CDK5R2"]
    Inflammation["Inflammation"]
    CDK5R2 -->|"associated with"| Inflammation
    ISG15["ISG15"]
    CDK5R2 -->|"therapeutic target"| ISG15
    HUB_GENES["HUB GENES"]
    CDK5R2 -->|"associated with"| HUB_GENES
    GRM5["GRM5"]
    CDK5R2 -->|"associated with"| GRM5
    SLC17A7["SLC17A7"]
    SLC17A7 -->|"therapeutic target"| CDK5R2
    GRM5["GRM5"]
    GRM5 -->|"therapeutic target"| CDK5R2
    SCN8A["SCN8A"]
    SCN8A -->|"therapeutic target"| CDK5R2
    STAT1["STAT1"]
    STAT1 -->|"therapeutic target"| CDK5R2
    FGF13["FGF13"]
    FGF13 -->|"therapeutic target"| CDK5R2
    SCN2B["SCN2B"]
    SCN2B -->|"therapeutic target"| CDK5R2
    SCN2B["SCN2B"]
    SCN2B -->|"associated with"| CDK5R2
    STAT1["STAT1"]
    STAT1 -->|"associated with"| CDK5R2
    GENES["GENES"]
    GENES -->|"associated with"| CDK5R2
    ISG15["ISG15"]
    ISG15 -->|"associated with"| CDK5R2
    SCN8A["SCN8A"]
    SCN8A -->|"associated with"| CDK5R2
    FGF13["FGF13"]
    FGF13 -->|"associated with"| CDK5R2
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"associated with"| CDK5R2
    SLC17A7["SLC17A7"]
    SLC17A7 -->|"associated with"| CDK5R2
    AND["AND"]
    AND -->|"associated with"| CDK5R2
    SLC17A7["SLC17A7"]
    CDK5R2 -->|"interacts with"| SLC17A7
    Genes["Genes"]
    CDK5R2 -->|"interacts with"| Genes
    SLC17A7["SLC17A7"]
    CDK5R2 -->|"associated with"| SLC17A7
    ISG15["ISG15"]
    ISG15 -->|"interacts with"| CDK5R2
    STAT1["STAT1"]
    STAT1 -->|"interacts with"| CDK5R2
    SCN2B["SCN2B"]
    SCN2B -->|"interacts with"| CDK5R2
    SCN8A["SCN8A"]
    SCN8A -->|"interacts with"| CDK5R2
    GRM5["GRM5"]
    GRM5 -->|"interacts with"| CDK5R2
    FGF13["FGF13"]
    FGF13 -->|"interacts with"| CDK5R2
    GRM5["GRM5"]
    GRM5 -->|"associated with"| CDK5R2
    neurodegeneration["neurodegeneration"]
    CDK5R2 -->|"implicated in"| neurodegeneration

Outgoing (29)

Target	Relation	Type	Str
Inflammation	associated_with	disease	0.65
Encephalitis	therapeutic_target	disease	0.65
Fgf	therapeutic_target	protein	0.60
STAT1	targets	gene	0.60
SCN8A	targets	gene	0.60
SLC17A7	targets	gene	0.60
FGF13	targets	gene	0.60
GRM5	associated_with	gene	0.60
Interferon Signaling	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60
STAT1	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
Cdk5	therapeutic_target	protein	0.60
FGF13	interacts_with	gene	0.60
GRM5	interacts_with	gene	0.60
ISG15	interacts_with	gene	0.60
SCN2B	interacts_with	gene	0.60
SCN8A	interacts_with	gene	0.60
STAT1	interacts_with	gene	0.60
Interferon	therapeutic_target	protein	0.60
ISG15	targets	gene	0.60
GRM5	targets	gene	0.60
SCN2B	targets	gene	0.60
SLC17A7	associated_with	protein	0.50
SLC17A7	interacts_with	protein	0.50

Incoming (23)

Source	Relation	Type	Str
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
ISG15	therapeutic_target	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
FGF13	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
SCN8A	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
FGF13	interacts_with	gene	0.50
GRM5	associated_with	gene	0.50
ISG15	interacts_with	gene	0.50
STAT1	interacts_with	gene	0.50
SCN2B	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK5R2 in their description or question text

No additional research found