| Gene Symbol | ent-gene-3d51813d |
| Chromosome | 7p15.3 |
| Primary Expression | Low in most healthy tissues, upregulated in disease states |
| Gene | GPNMB located on chromosome 7p15.3 |
| Protein size | ~560 amino acids (full-length), ~95 kDa |
| Soluble form | Generated via ADAM10/ADAM17-mediated shedding |
| Receptor | Integrin αvβ3 has been proposed as a binding partner |
| Cell adhesion and migration | Via integrin interactions |
| Tissue repair | Expressed in healing wounds and bone remodeling |
| Immune regulation | Modulates macrophage and microglial activity |
| Iron metabolism | Associates with ferroportin |
| Elevated levels | GPNMB concentration is significantly increased in AD CSF compared to healthy controls |
| Diagnostic utility | Moderate accuracy for distinguishing AD from controls (AUC ~0.75-0.85) |
| Progression marker | Higher baseline levels associated with faster cognitive decline |
| Correlation | Correlates with tau and Aβ42 levels |
| Peripheral detection | Soluble GPNMB can be measured in plasma and serum |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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