gene

SLC9A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC9A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

6Outgoing

1Incoming

0Experiments

0Debates

Summary

SLC9A1 encodes NHE1, a critical ion transporter regulating intracellular pH, cell volume, and sodium homeostasis. It plays essential roles in neuronal function, synaptic transmission, and is implicated in neurodegeneration, stroke, and cardiovascular disease.

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🧬 Gene Info

Gene Symbol	SLC9A1
Full Name	Sodium/Hydrogen Exchanger 1
Chromosome	1p36.11
Protein Family	SLC9A family (Na+/H+ exchangers)
Protein Type	Transporter
Function	is a critical ion transporter that regulates intracellular pH (pHi), cell volume, and sodium homeostasis in virtually all eukaryotic cells.
Molecular Weight	93 kDa
Amino Acids	815 aa
UniProt ID	P19634
NCBI Gene ID	6538
Ensembl ID	ENSG00000090020
OMIM	107310
GeneCards	SLC9A1
Human Protein Atlas	SLC9A1
Transport stoichiometry	1 Na+ inward : 1 H+ outward (electroneutral)
Associated Diseases	Alzheimer's disease, Parkinson's disease, Stroke
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC9A1 — AlphaFold P19634 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC9A1 — Sodium/Hydrogen Exchanger 1

gene · 1994 words

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Pathway Diagram

graph TD
    SLC9A1["SLC9A1"]
    Als{"Als"}
    SLC9A1 -->|"contributes to"| Als
    Ms{"Ms"}
    SLC9A1 -->|"contributes to"| Ms
    Stroke{"Stroke"}
    SLC9A1 -->|"contributes to"| Stroke
    SPP1["SPP1"]
    SLC9A1 -->|"contributes to"| SPP1
    GPNMB["GPNMB"]
    SLC9A1 -->|"contributes to"| GPNMB
    CX3CR1["CX3CR1"]
    SLC9A1 -->|"associated with"| CX3CR1
    neurodegeneration["neurodegeneration"]
    SLC9A1 -->|"implicated in"| neurodegeneration
    LGALS3["LGALS3"]
    LGALS3 -->|"contributes to"| SLC9A1
    style SLC9A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
SPP1	contributes_to	gene	0.60
GPNMB	contributes_to	gene	0.60
CX3CR1	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
LGALS3	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC9A1 in their description or question text

No additional research found