gene

SESN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

11Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for SESN3 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SESN3
Full Name	Sestrin 3
Chromosome	11q21<br>
Function	SESN3 shares functional similarities with other sestrins (SESN1 and SESN2):
Primary Expression	various tissues: - Brain: cortex, hippocampus, cerebellum - Liver, kidney, muscle - Inducible b
Molecular Weight	49 kDa
Pathways	signaling: - AMPK senses cellular energy status, mTOR, AMPK, AMPK signaling
UniProt ID	Q9Y5P4
NCBI Gene ID	286826
Ensembl ID	ENSG00000148231
GeneCards	SESN3
Human Protein Atlas	SESN3
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Metabolic Disease
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SESN3 — AlphaFold Q9Y5P4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SESN3 Gene

gene · 610 words

→

SESN3 Protein

protein · 715 words

→

Pathway Diagram

graph TD
    SESN3["SESN3"]
    SESN3 -->|"expressed in"| Ms["Ms"]
    SESN3 -->|"expressed in"| Als["Als"]
    SESN3 -->|"expressed in"| ATG7["ATG7"]
    SESN3 -->|"expressed in"| CSF1R["CSF1R"]
    SESN3 -->|"expressed in"| AND["AND"]
    SESN3 -->|"expressed in"| MICROGLIA["MICROGLIA"]
    SESN3 -->|"expressed in"| LGALS1["LGALS1"]
    SESN3 -->|"expressed in"| GPNMB["GPNMB"]
    LGALS3["LGALS3"] -->|"expressed in"| SESN3
    CD44["CD44"] -->|"expressed in"| SESN3

Outgoing (11)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
MICROGLIA	expressed_in	gene	0.60
LGALS3	expressed_in	gene	0.60
CSF1R	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
LGALS1	expressed_in	gene	0.60
GPNMB	expressed_in	gene	0.60
White Matter	expressed_in	brain_region	0.55

Incoming (2)

Source	Relation	Type	Str
LGALS3	expressed_in	gene	0.60
CD44	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SESN3 in their description or question text

No additional research found