protein

NPTX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPTX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

NPTX2 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with AD, ALI, Alzheimer. Connected to 86 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NPTX2
Full Name	Neuronal Pentraxin 2
Function	Neuronal Pentraxin 2 (NPTX2), also known as neuronal activity-regulated pentraxin (NARP), is a member of the pentraxin family of calcium-dependent ligand-binding proteins.
Molecular Weight	47 kDa
Pathways	COMPLEMENT, Complement
Ensembl ID	ENSG00000106290
GeneCards	NPTX2
Human Protein Atlas	NPTX2
Associated Diseases	AD, ALI, ALS, Alzheimer, Alzheimer's disease
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND, APOE
KG Connections	200 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    NPTX2["NPTX2"] -->|"interacts with"| C1Q["C1Q"]
    NPTX2["NPTX2"] -->|"regulates"| COMPLEMENT["COMPLEMENT"]
    NPTX2["NPTX2"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"biomarker for"| Ms["Ms"]
    NPTX2["NPTX2"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    NPTX2["NPTX2"] -->|"regulates"| Dementia["Dementia"]
    NPTX2["NPTX2"] -->|"regulates"| Inflammation["Inflammation"]
    NPTX2["NPTX2"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    NPTX2["NPTX2"] -->|"regulates"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"associated with"| Alzheimer["Alzheimer"]
    NPTX2["NPTX2"] -->|"regulates"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style NPTX2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style C1Q fill:#006494,stroke:#333,color:#e0e0e0
    style COMPLEMENT fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Frontotemporal_Dementia fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (135)

Target	Relation	Type	Str
Complement Activity	inhibits	process	0.95
Complement Activation	inhibits	process	0.95
Complement Activity	regulates	process	0.95
C1Q	binds	protein	0.95
Complement-Mediated Neurodegeneration	protects_against	process	0.90
Synapse Loss	protects_against	phenotype	0.90
Microglia	modulates	cell_type	0.90
Excitatory Synapse Loss	protects_against	phenotype	0.90
Microglia-Mediated Synapse Loss	inhibits	process	0.90
Cognitive Resilience	associated_with	phenotype	0.88
NEURODEGENERATION	protects_against	process	0.85
Frontotemporal Dementia	biomarker_for	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Alzheimer's Disease	downregulates	disease	0.80
synaptic plasticity	promotes	process	0.80
ALZHEIMER'S DISEASE	associated_with	entity	0.80
COMPLEMENT	regulates	pathway	0.72
C1Q	interacts_with	protein	0.72
cognitive decline	predicts	phenotype	0.70
AMPA receptor clustering	regulates	mechanism	0.70
Frontotemporal Dementia	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	biomarker_for	disease	0.65
Ftd	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
EXCITATORY_SYNAPSES	regulates	phenotype	0.64
SYNAPSE_ELIMINATION	inhibits	phenotype	0.64
Tau Phosphorylation	therapeutic_target	pathway	0.60
Amyloid	therapeutic_target	pathway	0.60
neurodegeneration	activates	disease	0.60
RAB10	interacts_with	gene	0.60
Amyloid	associated_with	pathway	0.60
AMPK	therapeutic_target	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Complement	regulates	pathway	0.60
neurodegeneration	associated_with	disease	0.60
PLCG2	interacts_with	gene	0.60
DEMENTIA	regulates	gene	0.60
Amyloid	inhibits	pathway	0.60
SYNAPSE	regulates	gene	0.60
Wnt	inhibits	pathway	0.60
Tau Phosphorylation	inhibits	pathway	0.60

Incoming (65)

Source	Relation	Type	Str
VGF	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
C1Q	activates	gene	0.60
C1Q	regulates	entity	0.60
C1Q	upregulates	entity	0.60
NRXN2	interacts_with	gene	0.60
NLGN1	interacts_with	gene	0.60
NLGN1	activates	gene	0.60
GPNMB	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
COMPLEMENT	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
PTN	associated_with	gene	0.60
AND	associated_with	gene	0.60
WNT	inhibits	gene	0.60
GMPR	inhibits	gene	0.60
GSK3	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	regulates	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
WNT	therapeutic_target	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
GSK3	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APOE4	interacts_with	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMPK	inhibits	gene	0.60
EXOSOMES	inhibits	gene	0.60
APOE3	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
WIF1	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
AMPK	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
GMPR	therapeutic_target	gene	0.60
MET	inhibits	gene	0.60
APOE	interacts_with	gene	0.60
ATP8B1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H6: Layer II–Specific Loss of NPTX2 and Aberrant AMPAR Traff	0.720	neurodegeneration	Entorhinal cortex layer II vulnerability

Mentioning Analyses (1)

Scientific analyses that reference this entity

Proteomics Differential Expression in AD CSF and Brain Tissue

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NPTX2 in their description or question text

No additional research found