CR2

Understanding Entity Pages

This page aggregates everything SciDEX knows about CR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Comprehensive page on CR2 (Complement Receptor Type 2, CD21), a receptor for C3d fragments expressed on B cells and follicular dendritic cells, implicated in Alzheimer's disease, multiple sclerosis, and systemic lupus erythematosus.

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graph TD
    CR2["CR2"]
    Autoimmune{"Autoimmune"}
    CR2 -->|"inhibits"| Autoimmune
    Als{"Als"}
    CR2 -->|"inhibits"| Als
    CR2 -->|"activates"| Als
    CR2 -->|"activates"| Autoimmune
    Alzheimer{"Alzheimer"}
    CR2 -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    CR2 -->|"associated with"| Dementia
    Ms{"Ms"}
    CR2 -->|"associated with"| Ms
    ALS{"ALS"}
    CR2 -->|"inhibits"| ALS
    Complement(["Complement"])
    CR2 -->|"inhibits"| Complement
    AQP4["AQP4"]
    CR2 -->|"inhibits"| AQP4
    Myelination(["Myelination"])
    CR2 -->|"inhibits"| Myelination
    GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
    CR2 -->|"associated with"| GENETIC_RISK_LOCI
    AQP4 -->|"inhibits"| CR2
    AQP4 -->|"activates"| CR2
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"inhibits"| CR2
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"inhibits"| CR2
    AQUAPORIN_4["AQUAPORIN-4"]
    AQUAPORIN_4 -->|"inhibits"| CR2
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"inhibits"| CR2
    AND["AND"]
    AND -->|"inhibits"| CR2
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"inhibits"| CR2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"inhibits"| CR2
    style CR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0