gene

DMT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DMT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

142Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

0Experiments

0Debates

Summary

Comprehensive information on DMT1 (SLC11A2), a divalent metal transporter involved in iron homeostasis and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DMT1
Full Name	Divalent Metal Transporter 1 (SLC11A2)
Aliases	SLC11A2, Divalent Metal Transporter 1
Chromosome	12q14.2
Protein Type	Transporter
Function	DMT1 is the primary transporter for non-heme iron uptake
Subcellular Localization	Plasma membrane, Endosomes, Lysosomes
Molecular Weight	54 kDa
Amino Acids	495 aa
Pathways	Ferroptosis, Inflammasome, Nf-Κb, Oxidative Stress, Synaptic Plasticity
UniProt ID	[P49281](https://www.uniprot.org/uniprot/P49281)
GeneCards	DMT1
Human Protein Atlas	DMT1
Associated Diseases	Parkinson's disease
Known Drugs/Compounds	Dietary iron, Dietary Iron
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, ATF4, AUTOPHAGY
KG Connections	142 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DMT1["DMT1"]
    Cancer{"Cancer"}
    DMT1 -->|"regulates"| Cancer
    Ms{"Ms"}
    DMT1 -->|"regulates"| Ms
    DMT1 -->|"activates"| Ms
    Als{"Als"}
    DMT1 -->|"contributes to"| Als
    DMT1 -->|"activates"| Cancer
    GPX4["GPX4"]
    DMT1 -->|"activates"| GPX4
    Ferroptosis(["Ferroptosis"])
    DMT1 -->|"activates"| Ferroptosis
    TFR1["TFR1"]
    DMT1 -->|"associated with"| TFR1
    FERROPTOSIS["FERROPTOSIS"]
    DMT1 -->|"contributes to"| FERROPTOSIS
    KEAP1["KEAP1"]
    DMT1 -->|"activates"| KEAP1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    DMT1 -->|"activates"| OXIDATIVE_STRESS
    HO_1["HO-1"]
    DMT1 -->|"activates"| HO_1
    TFR1 -->|"associated with"| DMT1
    TFR1 -->|"activates"| DMT1
    NCOA4["NCOA4"]
    NCOA4 -->|"contributes to"| DMT1
    P62["P62"]
    P62 -->|"activates"| DMT1
    FERROPORTIN["FERROPORTIN"]
    FERROPORTIN -->|"transports"| DMT1
    TFR1 -->|"transports"| DMT1
    AND["AND"]
    AND -->|"transports"| DMT1
    style DMT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (102)

Target	Relation	Type	Str
Iron Uptake	mediates	process	0.92
IRON METABOLISM	involved_in	entity	0.90
Dietary Iron	transports	chemical	0.90
Dietary Iron	targets	compound	0.90
Dietary iron	binds	compound	0.85
GPX4	associated_with	gene	0.70
Ferroptosis	activates	pathway	0.70
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Diabetes	activates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Als	contributes_to	disease	0.65
Cancer	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	inhibits	disease	0.65
NCOA4	activates	gene	0.60
SLC7A11	associated_with	gene	0.60
CYBB	activates	gene	0.60
PARK7	associated_with	gene	0.60
ATF4	activates	gene	0.60
Amyloid	inhibits	pathway	0.60
Protein Aggregation	inhibits	pathway	0.60
GPX4	activates	gene	0.60
KEAP1	activates	gene	0.60
NRF2	activates	gene	0.60
FTH1	associated_with	gene	0.60
TH	associated_with	gene	0.60
NCOA4	expressed_in	gene	0.60
TFR1	associated_with	gene	0.60
AIM2	regulates	gene	0.60
ROS	associated_with	gene	0.60
mitochondrial function	participates_in	pathway	0.60
NQO1	regulates	gene	0.60
Macrophage	transports	cell_type	0.60
Hepatocyte	transports	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
ROS	expressed_in	gene	0.60
ROS	activates	gene	0.60
Parkinson's disease	associated_with	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
AMYLOID	inhibits	gene	0.60
AND	expressed_in	gene	0.60

Incoming (40)

Source	Relation	Type	Str
CYTOKINES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
TNF-Α	activates	gene	0.60
TFR1	activates	gene	0.60
SLC7A11	activates	gene	0.60
TNFR1	activates	gene	0.60
TNF	activates	gene	0.60
FSP1	activates	gene	0.60
HO1	regulates	gene	0.60
NRF2	regulates	gene	0.60
AND	transports	gene	0.60
TFR1	associated_with	gene	0.60
FERROPORTIN	transports	gene	0.60
TFR1	transports	gene	0.60
BECLIN1	inhibits	gene	0.60
TAU	inhibits	gene	0.60
IREB2	expressed_in	gene	0.60
P62	inhibits	gene	0.60
FERROPORTIN	associated_with	gene	0.60
NRF2	activates	gene	0.60
HMOX1	activates	gene	0.60
APP	activates	gene	0.60
GSR	activates	gene	0.60
GPX4	activates	gene	0.60
VDAC2	activates	gene	0.60
LPCAT3	activates	gene	0.60
ROS	activates	gene	0.60
AMYLOID	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
LC3B	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
NCOA4	contributes_to	gene	0.60
P62	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DMT1 in their description or question text

No additional research found