concept

IRON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

7Hypotheses

0Analyses

24Outgoing

14Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IRON
Related Diseases	CANCER, FERROPTOSIS, ROS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

iron-calcium-glymphatic-convergence-alzheimers

general · 3516 words

→

Pathway Diagram

graph TD
    IRON["IRON"]
    IRON -->|"causes"| Ferroptosis["Ferroptosis"]
    IRON -->|"causes"| Phospholipid_Peroxidation["Phospholipid Peroxidation"]
    IRON -->|"upregulates"| Glycolysis["Glycolysis"]
    IRON -->|"mediates"| SNCA["SNCA"]
    IRON -->|"expressed in"| Brain["Brain"]
    Hemoglobin["Hemoglobin"] -->|"binds"| IRON
    Ferroportin["Ferroportin"] -->|"mediates"| IRON
    Ferritin["Ferritin"] -->|"binds"| IRON
    TFR1["TFR1"] -->|"mediates"| IRON
    TF["TF"] -->|"binds"| IRON
    Transferrin["Transferrin"] -->|"binds"| IRON
    Ferroptosis -->|"involved_in"| IRON
    ALOX15["ALOX15"] -->|"binds"| IRON

Outgoing (24)

Target	Relation	Type	Str
Myelination	involved_in	process	0.95
Oxidative Stress	causes	process	0.95
Ferroptosis	causes	process	0.95
Ferroptosis	mediates	process	0.95
oxidative stress	mediates	process	0.95
Phospholipid Peroxidation	causes	process	0.95
ferroptosis	drives	process	0.95
Neurotransmitter Synthesis	involved_in	process	0.95
Mitochondrial Metabolism	involved_in	process	0.95
Ferroptosis	associated_with	process	0.95
FTH1	binds	protein	0.95
FTMT	binds	protein	0.90
Microglia	associated_with	cell_type	0.90
hemoglobin	associated_with	protein	0.90
Brain	expressed_in	cell_type	0.85
Pro-inflammatory M1 Phenotype	associated_with	phenotype	0.85
oxidized polyunsaturated fatty acid phospholipids	mediates	compound	0.85
SNCA	mediates	protein	0.85
Microglial Transcriptional State	modulates	phenotype	0.85
Glycolysis	upregulates	pathway	0.85
Neurodegeneration	causes	process	0.80
FERROPTOSIS	causes	phenotype	0.72
FERROPTOSIS	activates	phenotype	0.72
ROS	activates	phenotype	0.64

Incoming (14)

Source	Relation	Type	Str
Ferroptosis	associated_with	process	0.95
Hemoglobin	binds	protein	0.95
Ferroportin	mediates	protein	0.95
Ferritin	binds	protein	0.95
TF	binds	protein	0.95
siderophores	binds	compound	0.95
Lactoferrin	inhibits	protein	0.93
Transferrin	binds	protein	0.90
TFRC	mediates	protein	0.90
TFRC	binds	protein	0.90
Transferrin	delivers	protein	0.90
Transferrin Receptor 2	transports	protein	0.80
CANCER	associated_with	disease	0.64
WNT	inhibits	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
SCFA-Producing Bacterial Depletion → Loss of Neuroprotective	0.700	neurodegeneration	What are the mechanisms by which gut mic
Iron Chelation Therapy Targeting the Labile Iron Pool	0.640	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Hepcidin-Iron Set Point Hypothesis	0.577	endocrinology	Does TRT-induced erythrocytosis actually

H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-S	0.550	-	Ferroptosis in ALS and motor neuron dise
IRP2-Iron Axis Modulation to Reduce Ferroptotic Vulnerabilit	0.398	neurodegeneration	Microglial subtypes in neurodegeneration

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRON in their description or question text

H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-Selected ALS Patients

Score: 0.550 · unknown disease · 2026-04-16

## Mechanistic Overview H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-Selected ALS Patients starts from the

IRP2-Iron Axis Modulation to Reduce Ferroptotic Vulnerability

Score: 0.398 · neurodegeneration · 2026-04-25

NOT RECOMMENDED. Contains a biochemical error that undermines the hypothesis. IREB2 binds to IRE sequences in the 5' UTR