gene 1,699 words KG: FTH1
Contents

FTH1 Gene — Ferritin Heavy Chain 1

🧬 Gene Info
Gene SymbolFTH1
Full NameFerritin Heavy Chain 1
Chromosome19q13.33
Protein FamilyFerritin heavy chain subunit
Functionis a hallmark of multiple neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS)[@ward2014].
Molecular Weight21 kDa
Exons4
PathwaysApoptosis, Blood-Brain Barrier, Ferroptosis, Metastasis, Mitophagy
UniProt IDP02794
NCBI Gene ID2495
Ensembl IDENSG00000196950
OMIM134790
GeneCardsFTH1
Human Protein AtlasFTH1
Ferroxidase centerLocated in FTH1, catalyzes Fe2+ -> Fe3+ oxidation
Associated DiseasesALS, Carcinoma, Hepatocellular Carcinoma, Parkinson's disease, stroke, Tumor
Known Drugs/Compoundsdimethyl malonate, paricalcitol
InteractionsACSL4, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections319 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Blood-Brain Barrier SPM Shuttle System
Score: 0.53

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Gandouling protection against brain injury in Wilson's disea
validation · proposed · Score: 0.90
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: expressed_in
ACTB Gene
gene · KG edge: associated_with
ATG7 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

paricalcitol activates FTH1
TFR1 inhibits FTH1
FTH1 inhibits GPX4
SQSTM1 associated_with FTH1
TNF associated_with FTH1
ELAVL1 associated_with FTH1
GPX4 associated_with FTH1
SLC7A11 associated_with FTH1
FTH1 associated_with P62
FTH1 associated_with MAP1LC3A

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