gene 871 words KG: FIS1
Contents

FIS1 Gene

🧬 Gene Info
Gene SymbolFIS1
Full NameFission 1 Mitochondrial Outer Membrane Protein
Chromosome7q22.1
Protein TypeMitochondrial outer membrane protein
FunctionFis1 Gene plays an important role in the study of neurodegenerative diseases
Molecular Weight17 kDa
PathwaysApoptosis, Autophagy, Lysosomal Degradation, Mitochondrial Function, Mitophagy
GeneCardsFIS1
Human Protein AtlasFIS1
Associated DiseasesAging, Als, Cardiomyopathy, Inflammation, Lymphoma
Known Drugs/CompoundsRAPAMYCIN
InteractionsAGING, AMPK, AND, APP, ATP, AUTOPHAGY
KG Connections359 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (8)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (10)

Astrocytes
cell · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: activates
Astrocytes
entity · KG edge: expressed_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates

Knowledge Graph (12 edges)

FIS1 regulates MITOCHONDRIAL_FRAGMENTATION
FIS1 associated_with CHOP
FIS1 associated_with NRF2
FIS1 associated_with MTOR
FIS1 associated_with BECLIN1
FIS1 associated_with BCL2
FIS1 associated_with TAAR1
FIS1 associated_with SIGMAR1
FIS1 associated_with MYD88
FIS1 associated_with PUMA

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