Contents

ESR2 — Estrogen Receptor Beta

🧬 Gene Info

Gene Symbol	ESR2
Full Name	Estrogen Receptor Beta
Chromosome	14q23.2
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	substantia nigra dopamine neurons - Neuroprotection: ERβ agonists protect against MPTP-induced parkinsonism - Clinical Relevance: Potential th
Pathways	PI3K, MAPK, Notch
UniProt ID	Q92731
NCBI Gene ID	2113
Ensembl ID	ENSG00000140009
GeneCards	ESR2
Human Protein Atlas	ESR2
DNA Binding Domain	Highly conserved, allowing binding to estrogen response elements
Ligand Binding Domain	Different from ERα, with distinct ligand selectivity
Transactivation Domains	AF-1 and AF-2 regions for co-regulator recruitment
Associated Diseases	ALS, Alzheimer, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AR, ATG, ATG7, ATP6AP2
KG Connections	269 knowledge graph edges
Databases	GeneCards HPA STRING

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