protein

ENDOPHILIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOPHILIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

23Outgoing

38Incoming

0Experiments

0Debates

Summary

Page for Endophilin Protein

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🔬 Protein Info

Gene Symbol	ENDOPHILIN
Molecular Weight	40 kDa
Pathways	P38 Mapk, OXIDATIVE PHOSPHORYLATION, Microrna
GeneCards	ENDOPHILIN
Human Protein Atlas	ENDOPHILIN
Interactions	DDIT3, DEPTOR, EGFR, EIF2A, EIF2AK3, ERN1
KG Connections	61 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    ENDOPHILIN["ENDOPHILIN"]
    P38_Mapk["P38 Mapk"]
    ENDOPHILIN -->|"activates"| P38_Mapk
    GABARAP["GABARAP"]
    ENDOPHILIN -->|"activates"| GABARAP
    GRP78["GRP78"]
    ENDOPHILIN -->|"activates"| GRP78
    VPS34["VPS34"]
    ENDOPHILIN -->|"activates"| VPS34
    IFNG["IFNG"]
    ENDOPHILIN -->|"activates"| IFNG
    cancer["cancer"]
    ENDOPHILIN -->|"activates"| cancer
    MAPK["MAPK"]
    ENDOPHILIN -->|"activates"| MAPK
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    ENDOPHILIN -->|"activates"| OXIDATIVE_PHOSPHORYLATION
    MTORC1["MTORC1"]
    ENDOPHILIN -->|"activates"| MTORC1
    Stem_Cell["Stem Cell"]
    ENDOPHILIN -->|"activates"| Stem_Cell
    Epithelial_Cell["Epithelial Cell"]
    ENDOPHILIN -->|"activates"| Epithelial_Cell
    disease["disease"]
    ENDOPHILIN -->|"activates"| disease
    Dendritic_Cell["Dendritic Cell"]
    ENDOPHILIN -->|"activates"| Dendritic_Cell
    CYP1A1["CYP1A1"]
    ENDOPHILIN -->|"activates"| CYP1A1
    DNA_DAMAGE["DNA DAMAGE"]
    ENDOPHILIN -->|"activates"| DNA_DAMAGE
    COLORECTAL_CANCER["COLORECTAL CANCER"]
    ENDOPHILIN -->|"activates"| COLORECTAL_CANCER
    Microrna["Microrna"]
    ENDOPHILIN -->|"activates"| Microrna
    Inflammatory_Bowel_Disease["Inflammatory Bowel Disease"]
    ENDOPHILIN -->|"activates"| Inflammatory_Bowel_Disease
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    ENDOPHILIN -->|"activates"| Reactive_Oxygen_Species
    RAPAMYCIN["RAPAMYCIN"]
    ENDOPHILIN -->|"activates"| RAPAMYCIN
    NUCLEUS["NUCLEUS"]
    ENDOPHILIN -->|"activates"| NUCLEUS
    ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    ENDOPHILIN -->|"activates"| ENDOPLASMIC_RETICULUM
    PEROXISOME["PEROXISOME"]
    ENDOPHILIN -->|"activates"| PEROXISOME
    LRRK2["LRRK2"]
    LRRK2 -->|"activates"| ENDOPHILIN
    Pi3K["Pi3K"]
    Pi3K -->|"activates"| ENDOPHILIN
    TFEB["TFEB"]
    TFEB -->|"activates"| ENDOPHILIN
    EGFR["EGFR"]
    EGFR -->|"activates"| ENDOPHILIN
    EIF2A["EIF2A"]
    EIF2A -->|"activates"| ENDOPHILIN
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| ENDOPHILIN
    STING1["STING1"]
    STING1 -->|"activates"| ENDOPHILIN

Outgoing (23)

Target	Relation	Type	Str
P38 Mapk	activates	pathway	0.50
MTORC1	activates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
GABARAP	activates	protein	0.50
GRP78	activates	protein	0.50
VPS34	activates	protein	0.50
IFNG	activates	gene	0.50
cancer	activates	disease	0.50
MAPK	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50

Incoming (38)

Source	Relation	Type	Str
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
Autophagy	activates	process	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
OPTN	activates	gene	0.50
DEPTOR	activates	gene	0.50
RIPK1	activates	gene	0.50
FIP200	activates	gene	0.50
GABA	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
PIK3C3	activates	gene	0.50
MAP1LC3A	activates	gene	0.50
MLST8	activates	gene	0.50
NBR1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
TFE3	activates	gene	0.50
RB1CC1	activates	gene	0.50
MAPK14	activates	gene	0.50
HMGB1	activates	gene	0.50
MAVS	activates	gene	0.50
TFEB	activates	protein	0.50
STAT3	activates	gene	0.50
OPTINEURIN	activates	protein	0.50
LRRK2	activates	gene	0.50
RPS6KB1	activates	gene	0.50
HSPA5	activates	gene	0.50
RHEB	activates	gene	0.50
RPTOR	activates	gene	0.50
STING1	activates	protein	0.50
HSP70	activates	protein	0.50
Pi3K	activates	pathway	0.50
DDIT3	activates	gene	0.50
MLKL	activates	gene	0.50
PPARG	activates	gene	0.50
GRB2	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOPHILIN in their description or question text

No additional research found