gene

PEN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

PEN2 (Presenilin Enhancer 2) is a component of the gamma-secretase complex that cleaves APP to generate amyloid-beta

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🧬 Gene Info

Gene Symbol	PSENEN
Aliases	Presenilin Enhancer 2
Chromosome	19q13.12
Protein Family	PEN-2 family (γ-secretase complex)
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Endoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight	12 kDa
Amino Acids	101 aa
Pathways	Angiogenesis
UniProt ID	Q9NQ75
GeneCards	PSENEN
Human Protein Atlas	PSENEN
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI
Interactions	A2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections	94 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PEN2 — AlphaFold Q9NQ75 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PEN2["PEN2"]
    Alzheimer{"Alzheimer"}
    PEN2 -->|"interacts with"| Alzheimer
    Tumor{"Tumor"}
    PEN2 -->|"interacts with"| Tumor
    Als{"Als"}
    PEN2 -->|"interacts with"| Als
    ALS{"ALS"}
    PEN2 -->|"interacts with"| ALS
    PSEN1["PSEN1"]
    PEN2 -->|"interacts with"| PSEN1
    DAPK1["DAPK1"]
    PEN2 -->|"interacts with"| DAPK1
    HSPG2["HSPG2"]
    PEN2 -->|"interacts with"| HSPG2
    IL1B["IL1B"]
    PEN2 -->|"interacts with"| IL1B
    APP["APP"]
    PEN2 -->|"interacts with"| APP
    EIF2AK2["EIF2AK2"]
    PEN2 -->|"interacts with"| EIF2AK2
    Cholesterol(["Cholesterol"])
    PEN2 -->|"interacts with"| Cholesterol
    Apoptosis(["Apoptosis"])
    PEN2 -->|"interacts with"| Apoptosis
    NCSTN["NCSTN"]
    NCSTN -->|"interacts with"| PEN2
    FAS["FAS"]
    FAS -->|"interacts with"| PEN2
    TNF["TNF"]
    TNF -->|"interacts with"| PEN2
    LMNA["LMNA"]
    LMNA -->|"interacts with"| PEN2
    APH1B["APH1B"]
    APH1B -->|"interacts with"| PEN2
    APOE["APOE"]
    APOE -->|"interacts with"| PEN2
    IL6["IL6"]
    IL6 -->|"interacts with"| PEN2
    SREBF1["SREBF1"]
    SREBF1 -->|"interacts with"| PEN2
    PSEN2["PSEN2"]
    PSEN2 -->|"interacts with"| PEN2
    A2M["A2M"]
    A2M -->|"interacts with"| PEN2
    DHCR24["DHCR24"]
    DHCR24 -->|"interacts with"| PEN2
    HMGCR["HMGCR"]
    HMGCR -->|"interacts with"| PEN2
    style PEN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
Gamma-Secretase Complex	interacts_with	protein	0.90
Alzheimer	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALZHEIMER	interacts_with	gene	0.60
Amyloid	interacts_with	pathway	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
PSEN1	regulates	gene	0.60
PSEN2	regulates	gene	0.60
Cholesterol	interacts_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Raf	interacts_with	protein	0.60
AMYLOID	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
Kinesin	interacts_with	protein	0.60
APP	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
Angiogenesis	regulates	pathway	0.60
PSEN2	interacts_with	entity	0.60
SREBF1	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
APP/PS1	associated_with	concept	0.50
Alzheimer'S Disease	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
AD	implicated_in	disease	0.50
Als	implicated_in	disease	0.50
Alzheimer's disease	implicated_in	disease	0.50
AMI	implicated_in	disease	0.50
RA	implicated_in	disease	0.50

Incoming (41)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	0.60
APP/PS1	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
ADAM10	regulates	gene	0.60
APH1B	regulates	gene	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
BACE2	regulates	gene	0.60
NCSTN	regulates	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
APP	associated_with	gene	0.60
ANG	associated_with	gene	0.60
FOXA2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PEN2 in their description or question text

No additional research found