gene

DCTN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

31Outgoing

12Incoming

0Experiments

0Debates

Summary

Gene: DCTN1 — Dynactin Subunit 1

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🧬 Gene Info

Gene Symbol	DCTN1
Full Name	Dynactin Subunit 1 (p150^Glued)
Aliases	Dynactin subunit p150^Glued
Protein Family	Dynactin complex
Function	DCTN1 plays critical roles in neuronal function
Subcellular Localization	Cytoplasm, neuronal axons, growth cones
Molecular Weight	150 kDa
Amino Acids	238 aa
UniProt ID	Q14203
GeneCards	DCTN1
Human Protein Atlas	DCTN1
Associated Diseases	ALS, frontotemporal dementia
Interactions	Actin, AND, ARF6, ATG, DYNACTIN, Dynein
KG Connections	43 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DCTN1 — AlphaFold Q14203 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DCTN1["DCTN1"]
    DCTN1 -->|"activates"| Als["Als"]
    DCTN1 -->|"activates"| ALS["ALS"]
    DCTN1 -->|"regulates"| Bipolar["Bipolar"]
    DCTN1 -->|"activates"| DYNEIN["DYNEIN"]
    DCTN1 -->|"activates"| AND["AND"]
    DCTN1 -->|"activates"| DYNACTIN["DYNACTIN"]
    DCTN1 -->|"activates"| POLE["POLE"]
    DCTN1 -->|"regulates"| DNAJB6["DNAJB6"]
    DNAJB6 -->|"regulates"| DCTN1
    DYNACTIN -->|"activates"| DCTN1
    DYNEIN -->|"activates"| DCTN1
    POLE -->|"activates"| DCTN1

Outgoing (31)

Target	Relation	Type	Str
ALS	associated_with	disease	0.70
ALS	activates	disease	0.65
Bipolar	regulates	disease	0.65
Als	activates	disease	0.65
LC3B	activates	gene	0.60
frontotemporal dementia	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Actin	activates	protein	0.60
DNAJB6	regulates	gene	0.60
Dynein	activates	protein	0.60
LAMP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
DYNEIN	activates	gene	0.60
DYNACTIN	activates	gene	0.60
POLE	activates	gene	0.60
FIG4	associated_with	gene	0.60
FUS	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
SETX	associated_with	gene	0.60
SPG11	associated_with	gene	0.60
TAF15	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
VAPB	associated_with	gene	0.60
VCP	associated_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
MAPK signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
AND	activates	gene	0.60

Incoming (12)

Source	Relation	Type	Str
PLK2	associated_with	gene	0.70
ALS2	associated_with	gene	0.60
ANG	associated_with	gene	0.60
DAO	associated_with	gene	0.60
ATP13A2	expressed_in	gene	0.60
ARF6	activates	gene	0.60
ATG	activates	gene	0.60
ALS	associated_with	gene	0.60
DNAJB6	regulates	gene	0.60
DYNACTIN	activates	gene	0.60
DYNEIN	activates	gene	0.60
POLE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DCTN1 in their description or question text

No additional research found