protein

DYNACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

26Outgoing

15Incoming

0Experiments

0Debates

Summary

DYNACTIN is a protein involved in neurodegeneration research. Key relationships include: transports, interacts with, implicated in. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DYNACTIN
Protein Family	Dynactin family
Function	Dynein alone exhibits relatively short "runs" along microtubule tracks, typically moving only 0.5-1 μm before dissociating [13].
Subcellular Localization	</strong></td><td>Cytoplasm, microtubules</td></tr> [@levy2006]
Molecular Weight	150 kDa
Pathways	Axonal Transport, Autophagy, Cholesterol
UniProt ID	Q14203
GeneCards	DYNACTIN
Human Protein Atlas	DYNACTIN
Associated Diseases	neurodegeneration
Interactions	Actin, AND, AUTOPHAGY, AXON, DCTN1, Dynein
KG Connections	41 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DYNACTIN — AlphaFold Q14203 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dynactin Protein

protein · 2656 words

→

Pathway Diagram

graph TD
    DYNACTIN["DYNACTIN"]
    DYNEIN["DYNEIN"]
    DYNACTIN -->|"interacts with"| DYNEIN
    Axonal_Transport(["Axonal Transport"])
    DYNACTIN -->|"transports"| Axonal_Transport
    AND["AND"]
    DYNACTIN -->|"interacts with"| AND
    NEURON["NEURON"]
    DYNACTIN -->|"transports"| NEURON
    TRAK1["TRAK1"]
    DYNACTIN -->|"interacts with"| TRAK1
    AXON["AXON"]
    DYNACTIN -->|"interacts with"| AXON
    MITOCHONDRIA["MITOCHONDRIA"]
    DYNACTIN -->|"transports"| MITOCHONDRIA
    Neuron["Neuron"]
    DYNACTIN -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    DYNACTIN -->|"implicated in"| neurodegeneration
    AXON -->|"interacts with"| DYNACTIN
    NEURON -->|"transports"| DYNACTIN
    TRAK1 -->|"interacts with"| DYNACTIN
    MITOCHONDRIA -->|"transports"| DYNACTIN
    style DYNACTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Infection	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Bipolar	regulates	disease	0.65
DNAJB6	regulates	gene	0.60
Dynein	activates	protein	0.60
Axonal Transport	transports	pathway	0.60
LDLR	activates	gene	0.60
RAB7	interacts_with	gene	0.60
Actin	activates	protein	0.60
DYNEIN	activates	gene	0.60
POLE	activates	gene	0.60
DCTN1	activates	gene	0.60
DYNEIN	interacts_with	gene	0.60
NEURON	transports	gene	0.60
TRAK1	interacts_with	gene	0.60
AXON	interacts_with	gene	0.60
MITOCHONDRIA	transports	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Cholesterol	interacts_with	pathway	0.60
AND	interacts_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
KINESIN-1	interacts_with	protein	0.50
DYNEIN	co_discussed	protein	0.50
KINESIN-1	co_discussed	protein	0.50

Incoming (15)

Source	Relation	Type	Str
DYNEIN	interacts_with	gene	0.60
RILP	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
DCTN1	activates	gene	0.60
DYNEIN	activates	gene	0.60
AND	activates	gene	0.60
AXON	interacts_with	gene	0.60
NEURON	transports	gene	0.60
TRAK1	interacts_with	gene	0.60
MITOCHONDRIA	transports	gene	0.60
SREBP2	activates	gene	0.60
AND	interacts_with	gene	0.60
DNAJB6	regulates	gene	0.60
POLE	activates	gene	0.50
MIRO1	regulates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DYNACTIN in their description or question text

No additional research found