gene

CDKN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

473Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Cell cycle regulator with critical roles in neuronal survival, DNA damage response, and neurodegeneration

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🧬 Gene Info

Gene Symbol	CDKN1A
Full Name	Cyclin-Dependent Kinase Inhibitor 1A
Chromosome	6p21.31
Function	is a key cell cycle regulator that mediates p53-dependent cell cycle arrest.
Amino Acids	164 aa
Pathways	TGF-β
UniProt ID	P38936
NCBI Gene ID	1026
Ensembl ID	ENSG00000100994
GeneCards	CDKN1A
Human Protein Atlas	CDKN1A
N-terminal domain	binds and inhibits CDK2/cyclin E and CDK1/cyclin B complexes
C-terminal domain	interacts with PCNA (proliferating cell nuclear antigen), blocking DNA replication
p53-binding region	contains p53-responsive elements for transcriptional activation
Neurons	particularly in post-mitotic differentiated neurons
Associated Diseases	Aging, Als, Alzheimer, Cancer, Cellular Senescence
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AGING, AGO2, AKT, AND, APOPTOSIS
KG Connections	470 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDKN1A — AlphaFold P38936 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A

gene · 922 words

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Pathway Diagram

graph TD
    CDKN1A["CDKN1A"] -->|"regulates"| Senescence["Senescence"]
    CDKN1A["CDKN1A"] -->|"regulates"| Ms["Ms"]
    CDKN1A["CDKN1A"] -->|"regulates"| Autism["Autism"]
    CDKN1A["CDKN1A"] -->|"associated"| Als["Als"]
    CDKN1A["CDKN1A"] -->|"associated"| Ms_1["Ms"]
    CDKN1A["CDKN1A"] -->|"therapeutic target"| Ms_2["Ms"]
    CYCS["CYCS"] -.->|"inhibits"| CDKN1A["CDKN1A"]
    CD4["CD4"] -->|"interacts"| CDKN1A["CDKN1A"]
    MAPK3["MAPK3"] -->|"interacts"| CDKN1A["CDKN1A"]
    ZAP70["ZAP70"] -->|"interacts"| CDKN1A["CDKN1A"]
    style CDKN1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (294)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescent Cells	expressed_in	cell_type	0.95
Autophagosome	associated_with	cell_type	0.90
Cellular Senescence	associated_with	phenotype	0.90
Alzheimer'S Disease	therapeutic_target	disease	0.88
Proliferative Arrest	causes	process	0.85
Proliferative Arrest	inhibits	process	0.85
Pulmonary Vascular Endothelial Cell Senescence	biomarker_for	process	0.85
Cellular Senescence	biomarker_for	process	0.80
Senescence	biomarker_for	process	0.80
ROS	activates	gene	0.80
Als	activates	disease	0.75
Cancer	activates	disease	0.75
Senescence	regulates	disease	0.75
Mapk	therapeutic_target	pathway	0.70
CANCER	activates	gene	0.70
P62	regulates	gene	0.70
GENES	regulates	gene	0.70
P21	inhibits	gene	0.70
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Synucleinopathy	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Senescence	therapeutic_target	disease	0.65
Ferroptosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Autism	regulates	disease	0.65
Hepatitis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Ms	regulates	disease	0.65
Senescence	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Aging	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Viral Infection	regulates	disease	0.65

Incoming (179)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CDKN1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
SQSTM1	mediates	protein	0.95
Mir-302B	targets	biomarker	0.90
XHP	upregulates	drug	0.90
MIR-302B	targets	gene	0.90
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
SIRT1	downregulates	protein	0.85
Autophagy Deficiency	causes	phenotype	0.85
SQSTM1	binds_to	gene	0.80
telomere shortening	upregulates	phenotype	0.80
Srt2104	downregulates	drug	0.80
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.80
MIRNAS	regulates	gene	0.70
P53	activates	gene	0.70
MAPK3	therapeutic_target	gene	0.70
SYNUCLEINOPATHY	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
MICRORNAS	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
CYCS	inhibits	gene	0.60
RNA	regulates	gene	0.60
CCNG2	inhibits	gene	0.60
CCND1	regulates	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
FURIN	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
P53	expressed_in	gene	0.60
DNA	regulates	gene	0.60
ATG	activates	gene	0.60
GENES	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
RNA	encodes	gene	0.60
DNA	encodes	gene	0.60
AND	inhibits	gene	0.60
ROS	associated_with	gene	0.60
MTORC1	regulates	gene	0.60
rapamycin	targets	drug	0.60
OXIDATIVE STRESS	activates	gene	0.60
TPRKB	activates	gene	0.60
TSC22D3	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
MIR-302B	inhibits	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
EXOSOMES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDKN1A in their description or question text

No additional research found