gene

ESRRB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESRRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

9Outgoing

2Incoming

0Experiments

0Debates

Summary

Estrogen-Related Receptor Beta - a nuclear receptor involved in mitochondrial function, stem cell pluripotency, and neurodegenerative disease pathogenesis

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🧬 Gene Info

Gene Symbol	ESRRB
Aliases	Estrogen-Related Receptor Beta
Chromosome	14q24.3
Protein Type	Receptor
Function	is an orphan nuclear receptor that belongs to the estrogen-related receptor (ERR) subfamily of nuclear receptors.
Primary Expression	various peripheral tissues [6](https://pubmed
Amino Acids	503 aa
Pathways	Stem Cell
Ensembl ID	ENSG00000119715
GeneCards	ESRRB
Human Protein Atlas	ESRRB
Associated Diseases	neurodegeneration
Interactions	CANCER, CDKN1A, MYC, SMAD2, SMAD7
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESRRB Gene

gene · 2756 words

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Pathway Diagram

graph TD
    ESRRB["ESRRB"]
    Tumor{"Tumor"}
    ESRRB -->|"activates"| Tumor
    Prostate_Cancer{"Prostate Cancer"}
    ESRRB -->|"contributes_to"| Prostate_Cancer
    Cancer{"Cancer"}
    ESRRB -->|"activates"| Cancer
    Als{"Als"}
    ESRRB -->|"contributes_to"| Als
    Breast_Cancer{"Breast Cancer"}
    ESRRB -->|"contributes_to"| Breast_Cancer
    CDKN1A["CDKN1A"]
    ESRRB -->|"inhibits"| CDKN1A
    CANCER["CANCER"]
    ESRRB -->|"activates"| CANCER
    MYC["MYC"]
    ESRRB -->|"activates"| MYC
    Stem_Cell(["Stem Cell"])
    ESRRB -->|"regulates"| Stem_Cell
    SMAD7["SMAD7"]
    SMAD7 -->|"activates"| ESRRB
    SMAD2["SMAD2"]
    SMAD2 -->|"inhibits"| ESRRB
    neurodegeneration["neurodegeneration"]
    ESRRB -->|"implicated_in"| neurodegeneration

Outgoing (9)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Prostate Cancer	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Breast Cancer	contributes_to	disease	0.65
CANCER	activates	gene	0.60
Stem Cell	regulates	pathway	0.60
CDKN1A	inhibits	gene	0.60
MYC	activates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
SMAD7	activates	gene	0.60
SMAD2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ESRRB in their description or question text

No additional research found