concept

CALCIUM SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

7Debates

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💡 Concept Info

Name	CALCIUM SIGNALING
Key Genes/Proteins	ADAM10, AMYLOID, AMYLOID-BETA, APOE, AQP4, BDNF
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcium Signaling Pathway in Neurodegeneration

mechanism · 3338 words

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Pathway Diagram

graph TD
    CALCIUM_SIGNALING["CALCIUM SIGNALING"]
    CALCIUM_SIGNALING -->|"interacts"| Phagocytosis["Phagocytosis"]
    CALCIUM_SIGNALING -->|"interacts"| Apoptosis["Apoptosis"]
    CALCIUM_SIGNALING -->|"interacts"| Akt["Akt"]
    CALCIUM_SIGNALING -->|"interacts"| Pi3K["Pi3K"]
    CALCIUM_SIGNALING -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    BCL2["BCL2"] -->|"regulates"| CALCIUM_SIGNALING
    JUN["JUN"] -->|"regulates"| CALCIUM_SIGNALING
    MCOLN1["MCOLN1"] -->|"regulates"| CALCIUM_SIGNALING
    BANG["BANG"] -->|"activates"| CALCIUM_SIGNALING
    GPR37["GPR37"] -->|"activates"| CALCIUM_SIGNALING
    GENES["GENES"] -->|"regulates"| CALCIUM_SIGNALING
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| CALCIUM_SIGNALING
    Als["Als"] -->|"regulates"| CALCIUM_SIGNALING
    Ms["Ms"] -->|"regulates"| CALCIUM_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| CALCIUM_SIGNALING

Outgoing (120)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Neuroregeneration	regulates	process	0.90
Macrophage Phagocytosis	mediates	process	0.90
Neuronal Cell Death	mediates	process	0.85
mitochondrial function	regulates	process	0.85
Neuronal Dendrites	involved_in	cell_type	0.80
neurons	active_in	cell_type	0.80
synaptic plasticity	crosstalk_with	pathway	0.70
astrocytes	active_in	cell_type	0.70
tau seeding cargo packaging	regulates	process	0.70
microglial state transitions	regulates	phenotype	0.70
neural stem cells	active_in	cell_type	0.70
CDK5	regulates	gene	0.65
NEURODEGENERATION	treats	phenotype	0.65
INFLAMMATION	causes	phenotype	0.65
oligodendrocytes	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
pericytes	active_in	cell_type	0.60
hippocampus	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Neuron	associated_with	cell_type	0.50
GLUTAMATE	associated_with	phenotype	0.50
T CELL	co_discussed	entity	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
NEURON	co_discussed	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
MITOCHONDRIA	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
NEURONS	co_discussed	cell_type	0.50
IL-17	expressed_in	concept	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
Fibroblast	regulates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Oligodendrocyte	activates	cell_type	0.50
AGING	associated_with	phenotype	0.50
CASP3	associated_with	gene	0.50

Incoming (490)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
MAMs	mediates	process	0.90
GRIN1	mediates	gene	0.90
Er-Plasma Membrane Junctions	mediates	mechanism	0.90
ANNEXINS	involved_in	protein	0.90
ER-mitochondria distance	modulates	mechanism	0.90
ER-Mitochondria Contact Sites	involved_in	mechanism	0.90
APOE	inhibits	gene	0.90
MERCS	regulates	process	0.90
ER-Plasma Membrane Junctions	mediates	mechanism	0.85
P2 RECEPTORS	regulates	receptor	0.85
PKC	participates_in	gene	0.85
APOE	associated_with	gene	0.85
NEUROGRANIN	activates	protein	0.80
Alzheimer's disease	involves	disease	0.80
Voltage-Gated Calcium Channels	regulates	protein	0.80
neuroinflammation	involves	disease	0.80
Als	regulates	disease	0.80
APOPTOSIS	therapeutic_target	gene	0.80
Alzheimer	therapeutic_target	disease	0.80
Rizzuto R	involved_in	protein	0.75
neurons	active_in	cell_type	0.75
GLUCOCORTICOID RECEPTOR	regulates	receptor	0.75
AQP4	involved_in	protein	0.75
synaptic plasticity	mediates	pathway	0.70
MCOLN1	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
Huntington's disease	involves	disease	0.70
NEURODEGENERATION	regulates	gene	0.70
Neurodegeneration	regulates	disease	0.70
MITOPHAGY	regulates	gene	0.70
BCL2	regulates	protein	0.70
PLCG2	regulates	protein	0.70
ALZHEIMER	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
AUTOPHAGY	activates	gene	0.70
beta-amyloid oligomers	inhibits	protein	0.70
LIPID PEROXIDATION	protects_against	phenotype	0.65
Inflammation	regulates	disease	0.65
VEGFA	regulates	gene	0.65
CREB	participates_in	gene	0.65
CASP3	regulates	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
NEURONS	regulates	cell_type	0.65
LDHB	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
STROKE	expressed_in	gene	0.60
IL-17	associated_with	gene	0.60
DEMENTIA	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.632	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Closed-loop transcranial focused ultrasound to restore hippo	0.551	Alzheimer's disease	Circuit-level neural dynamics in neurode