gene

GADD45B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD45B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

20Outgoing

6Incoming

0Experiments

0Debates

Summary

GADD45B - Growth Arrest and DNA Damage Inducible Beta linked to DNA repair and stress response in neurodegeneration

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🧬 Gene Info

Gene Symbol	GADD45B
Full Name	Growth Arrest and DNA Damage Inducible Beta
Aliases	Growth Arrest and DNA Damage 45 Beta
Chromosome	19p13.3
Function	GADD45B participates in several critical cellular processes
Molecular Weight	18 kDa
Amino Acids	165 aa
Pathways	MAPK, NF-κB, NF-κB signaling, MAPK pathway
UniProt ID	Q9ULLI
NCBI Gene ID	10988
Ensembl ID	ENSG00000099899
OMIM	604411
GeneCards	GADD45B
Human Protein Atlas	GADD45B
Associated Diseases	neurodegeneration
Interactions	CDKN1A, FERROPTOSIS, GADD45A, GADD45G, MET, PPP3CC
KG Connections	26 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GADD45B — AlphaFold Q9ULLI Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GADD45B — Growth Arrest and DNA Damage Inducible Beta

gene · 1763 words

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GADD45B Protein

protein · 2299 words

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Pathway Diagram

graph TD
    GADD45B["GADD45B"]
    Ms{"Ms"}
    GADD45B -->|"activates"| Ms
    Depression{"Depression"}
    GADD45B -->|"activates"| Depression
    GADD45B -->|"expressed in"| Ms
    Als{"Als"}
    GADD45B -->|"inhibits"| Als
    Epilepsy{"Epilepsy"}
    GADD45B -->|"inhibits"| Epilepsy
    GADD45B -->|"inhibits"| Ms
    GADD45G["GADD45G"]
    GADD45B -->|"activates"| GADD45G
    MET["MET"]
    GADD45B -->|"activates"| MET
    Neurogenesis(["Neurogenesis"])
    GADD45B -->|"activates"| Neurogenesis
    GADD45B -->|"regulates"| GADD45G
    Epigenetic(["Epigenetic"])
    GADD45B -->|"expressed in"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    GADD45B -->|"expressed in"| Dna_Methylation
    GADD45A["GADD45A"]
    GADD45A -->|"activates"| GADD45B
    GADD45A -->|"regulates"| GADD45B
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| GADD45B
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"associated with"| GADD45B
    P53["P53"]
    P53 -->|"associated with"| GADD45B
    SOD2["SOD2"]
    SOD2 -->|"activates"| GADD45B
    style GADD45B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
PPP3CC	activates	gene	0.80
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Epilepsy	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Ferroptosis	activates	pathway	0.60
Neurogenesis	activates	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
CDKN1A	activates	gene	0.60
Apoptosis	associated_with	pathway	0.60
Necroptosis	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
APOPTOSIS	associated_with	gene	0.60
GADD45G	activates	gene	0.60
MET	activates	gene	0.60
GADD45G	regulates	gene	0.60
Tgf-Β	associated_with	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
FERROPTOSIS	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
P53	associated_with	gene	0.60
SOD2	activates	gene	0.60
GADD45A	activates	gene	0.60
GADD45A	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GADD45B in their description or question text

No additional research found