protein 675 words KG: CD68PROTEIN
Contents

CD68 Protein (Macrosialin)

🔬 Protein Info
Gene SymbolCD68
Full NameCluster of Differentiation 68
AliasesMacrosialin
Chromosome17p13.1
FunctionCD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expressionmonocytes and macrophages
Amino Acids22 aa
PathwaysGlial Phagocytosis
NCBI Gene ID968
Ensembl IDENSG00000129226
OMIM609453
GeneCardsCD68
Human Protein AtlasCD68
N-terminal leader peptide20-22 amino acids
Large mucin-like domainContains multiple O-linked glycosylation sites
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, cancer
InteractionsABCA1, ACSL4, Actin, AGING, AIF1, AKT
KG Connections691 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (12)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (15)

Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)