gene 576 words KG: CD68
Contents

CD68 Gene

🧬 Gene Info
Gene SymbolCD68
Full NameCluster of Differentiation 68
AliasesMacrosialin
Chromosome17p13.1
FunctionCD68 is a member of the lysosomal-associated membrane protein (LAMP) family:
Primary Expressionmonocytes and macrophages
Amino Acids22 aa
PathwaysGlial Phagocytosis
NCBI Gene ID968
Ensembl IDENSG00000129226
OMIM609453
GeneCardsCD68
Human Protein AtlasCD68
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, cancer
InteractionsABCA1, ACSL4, Actin, AGING, AIF1, AKT
KG Connections688 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (45)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
APOE-Dependent Autophagy Restoration
Score: 0.89
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
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Related Analyses (15)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (14)

Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
AIF1 Gene
gene · KG edge: biomarker_for
ALDH1L1
gene · KG edge: biomarker_for
ANXA1 — Annexin A1
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CD163 associated_with CD68
MMP9 biomarker_for CD68
CD14 associated_with CD68
CD68 biomarker_for MMP2
S100A8 expressed_in CD68
CD47 inhibits CD68
GFAP expressed_in CD68
MMP9 inhibits CD68
TNF inhibits CD68
TLR4 inhibits CD68

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