gene

TMEM119

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM119: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

230Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TMEM119 gene page - highly specific microglial marker in the CNS involved in bone morphogenetic protein signaling and neurodegenerative disease

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🧬 Gene Info

Gene Symbol	TMEM119
Full Name	Transmembrane Protein 119
Aliases	TMEM119 gene page
Chromosome	12q14.1
Primary Expression	CNS Microglia, Bone, Osteoblasts
Molecular Weight	47 kDa
Amino Acids	386 aa
Exons	5
Pathways	COMPLEMENT, NF-kB signaling, purinergic signaling, senescence, ubiquitin-proteasome
UniProt ID	Q2M2W4
NCBI Gene ID	344758
Ensembl ID	ENSG00000145681
OMIM	616485
GeneCards	TMEM119
Human Protein Atlas	TMEM119
Associated Diseases	Aging, Als, Inflammation, Neuroinflammation
Interactions	AIF1, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND, APOE
KG Connections	230 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TMEM119 — AlphaFold Q2M2W4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TMEM119 — Transmembrane Protein 119

gene · 1505 words

→

TMEM119 Protein

protein · 606 words

→

Pathway Diagram

graph TD
    TMEM119["TMEM119"]
    Neuroinflammation{"Neuroinflammation"}
    TMEM119 -->|"biomarker for"| Neuroinflammation
    Inflammation{"Inflammation"}
    TMEM119 -->|"biomarker for"| Inflammation
    Neurodegeneration{"Neurodegeneration"}
    TMEM119 -->|"biomarker for"| Neurodegeneration
    Dementia{"Dementia"}
    TMEM119 -->|"biomarker for"| Dementia
    Als{"Als"}
    TMEM119 -->|"biomarker for"| Als
    Alzheimer{"Alzheimer"}
    TMEM119 -->|"biomarker for"| Alzheimer
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    TMEM119 -->|"biomarker for"| Traumatic_Brain_Injury
    Parkinson{"Parkinson"}
    TMEM119 -->|"biomarker for"| Parkinson
    TMEM119 -->|"associated with"| Inflammation
    TMEM119 -->|"associated with"| Neuroinflammation
    TMEM119 -->|"activates"| Alzheimer
    ALS{"ALS"}
    TMEM119 -->|"biomarker for"| ALS
    UCHL1["UCHL1"]
    UCHL1 -->|"interacts with"| TMEM119
    GFAP["GFAP"]
    GFAP -->|"interacts with"| TMEM119
    P2RY12["P2RY12"]
    P2RY12 -->|"expressed in"| TMEM119
    NFL["NFL"]
    NFL -->|"interacts with"| TMEM119
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| TMEM119
    AMYLOID_BETA["AMYLOID-BETA"]
    AMYLOID_BETA -->|"activates"| TMEM119
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"biomarker for"| TMEM119
    ALZHEIMER_S_DISEASE -->|"biomarker for"| TMEM119
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| TMEM119
    AND["AND"]
    AND -->|"expressed in"| TMEM119
    GAIN["GAIN"]
    GAIN -->|"biomarker for"| TMEM119
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"biomarker for"| TMEM119
    style TMEM119 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (135)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Microglia	biomarker_for	cell_type	0.80
Inflammation	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
MACROPHAGES	activates	cell_type	0.65
Glioblastoma	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
AMYLOID	interacts_with	protein	0.65
DAM microglia	expressed_in	cell_type	0.65
unfolded protein response	participates_in	pathway	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
TREM2	activates	gene	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Traumatic Brain Injury	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Astrocyte	biomarker_for	cell_type	0.60
Oligodendrocyte	biomarker_for	cell_type	0.60
Neuron	biomarker_for	cell_type	0.60
Endothelial	biomarker_for	cell_type	0.60
T Cell	biomarker_for	cell_type	0.60
COMPLEMENT	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
GENES	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
Complement	biomarker_for	pathway	0.60
TNF	inhibits	gene	0.60
ASTROCYTES	biomarker_for	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
INOS	biomarker_for	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
UBIQUITIN	interacts_with	gene	0.60
IBA1	expressed_in	gene	0.60
CYBB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60

Incoming (95)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
SALL1	activates	gene	0.65
MICROGLIA	treats	cell_type	0.65
APOE	activates	gene	0.65
P2RY12	activates	gene	0.65
C1QB	biomarker_for	gene	0.60
CX3CR1	activates	gene	0.60
GFAP	inhibits	gene	0.60
GBM	biomarker_for	gene	0.60
IBA1	biomarker_for	gene	0.60
AND	expressed_in	gene	0.60
CMTM6	expressed_in	gene	0.60
STAT1	activates	gene	0.60
GFAP	interacts_with	gene	0.60
P2RY12	expressed_in	gene	0.60
NFL	interacts_with	gene	0.60
GAIN	biomarker_for	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
IBA1	expressed_in	gene	0.60
GBM	expressed_in	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
C1QA	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
CD68	expressed_in	gene	0.60
CYBB	biomarker_for	gene	0.60
AIF1	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
UCHL1	interacts_with	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
FCRLS	expressed_in	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
CMTM6	biomarker_for	gene	0.60
NLRP3	inhibits	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
AMYLOID-BETA	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
BRAIN INJURY	biomarker_for	gene	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity