gene 583 words KG: CCL3
Contents

CCL3 Gene

🧬 Gene Info
Gene SymbolCCL3
AliasesMIP-1α, LD78β
Chromosome17q12
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious cell types including: - Activated macrophages and monocytes - T cells and B cells - Neurons and glial cells (in CNS) - En
Molecular Weight10 kDa
Amino Acids99 aa
PathwaysAkt, Amyloid, Autophagy, Chaperone, Exocytosis
UniProt IDP10147
Ensembl IDENSG00000108175
OMIM182283
GeneCardsCCL3
Human Protein AtlasCCL3
Associated DiseasesAls, Alzheimer, Cancer, Dementia, Inflammation, Ms
Known Drugs/CompoundsGW201
InteractionsAGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections301 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (13)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CCL3 activates C1Q
PANX1 regulates CCL3
S100B regulates CCL3
RELB regulates CCL3
P2RY1 regulates CCL3
CASP3 regulates CCL3
SOCS3 regulates CCL3
TRPA1 regulates CCL3
CXCL2 regulates CCL3
SNAP25 regulates CCL3

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