Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about araf: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARAF |
| Full Name | A-Raf Proto-Oncogene, Serine/Threonine Kinase |
| Protein Family | RAF family, MAP3K |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase belonging to the RAF family (along with BRAF and RAF1/C-Raf). |
| Primary Expression | Ubiquitous, highest in brain, heart, lung |
| Molecular Weight | 67 kDa |
| Amino Acids | 606 aa |
| Pathways | MAPK, MAPK pathway |
| UniProt ID | [P04003](https://www.uniprot.org/uniprot/P04003) |
| Ensembl ID | ENSG00000078061 |
| GeneCards | ARAF |
| Human Protein Atlas | ARAF |
| CR1 (Conserved Region 1) | Contains the RAS-binding domain (RBD) and a cysteine-rich domain (CRD) that mediates membrane localization and interactions with RAS-GTP [@map2021] |
| CR2 | A regulatory region containing a serine-rich domain with phosphorylation sites that control kinase activity |
| Associated Diseases | neurodegeneration |
| Interactions | ATG12, ATG16L1, ATG3, ATG7, ATG9A, AUTOPHAGY |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ARAF["ARAF"]
ARAF -->|"activates"| Cancer["Cancer"]
ARAF -->|"activates"| CANCER["CANCER"]
ARAF -->|"activates"| BECLIN1["BECLIN1"]
ARAF -->|"activates"| ATG12["ATG12"]
ARAF -->|"activates"| MYC["MYC"]
ARAF -->|"activates"| CDK12["CDK12"]
ARAF -->|"activates"| ATG3["ATG3"]
ARAF -->|"activates"| ATG7["ATG7"]
ATG9A["ATG9A"] -->|"activates"| ARAF| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARAF | data_in | dataset_row | 0.00 |
| Cancer | activates | disease | 0.75 |
| CANCER | activates | gene | 0.70 |
| MYC | activates | gene | 0.60 |
| CDK12 | activates | gene | 0.60 |
| ATG3 | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| CDK4 | activates | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| ERK1 | implicated_in | gene | 0.60 |
| BRAF | implicated_in | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| ERK | implicated_in | gene | 0.60 |
| RAS | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| Erk Signaling | activates | pathway | 0.60 |
| BECLIN1 | activates | gene | 0.60 |
| ATG12 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARAF | data_in | dataset_row | 0.00 |
| ATG9A | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning araf in their description or question text
No additional research found