protein

NEAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

293Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

A nuclear long non-coding RNA essential for paraspeckle formation and implicated in neurodegenerative diseases including ALS, AD, and PD

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🔬 Protein Info

Gene Symbol	NEAT1
Chromosome	11q13.1
Function	is a nuclear long non-coding RNA that serves as the essential structural scaffold for paraspeckles — nuclear bodies involved in gene expression regulation.
Primary Expression	Ubiquitous, highest in brain, heart, muscle
Subcellular Localization	Nucleus (paraspeckles)
Molecular Weight	23 kDa
Pathways	Blood-Brain Barrier, Endocytosis, Epigenetic, Microrna, Oxidative Stress
GeneCards	NEAT1
Human Protein Atlas	NEAT1
Associated Diseases	ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Atherosclerosis, cancer, Colorectal Cancer
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX Hypotheses	A-Tract Bulge Conserved Motifs Enable Selective Ta
KG Connections	293 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NEAT1 (Nuclear Enriched Abundant Transcript 1)

protein · 1147 words

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Pathway Diagram

flowchart TD
    NEAT1["NEAT1"] -->|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    NEAT1["NEAT1"] -->|"regulates"| TDP_43["TDP-43"]
    NEAT1["NEAT1"] -->|"associated with"| Alzheimer_s_disease["Alzheimer's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Parkinson_s_disease["Parkinson's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Huntington_s_disease["Huntington's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Alzheimer_s_disease["Alzheimer's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Parkinson_s_disease["Parkinson's disease"]
    NEAT1["NEAT1"] -->|"biomarker for"| Huntington_s_disease["Huntington's disease"]
    NEAT1["NEAT1"] -->|"associated with"| Ms["Ms"]
    NEAT1["NEAT1"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
    NEAT1["NEAT1"] -->|"regulates"| Als["Als"]
    NEAT1["NEAT1"] -->|"activates"| Ms["Ms"]
    style NEAT1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style TDP_43 fill:#006494,stroke:#333,color:#e0e0e0
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington_s_disease fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (186)

Target	Relation	Type	Str
PARKINSON'S DISEASE	upregulates	disease	0.95
ALS	upregulates	disease	0.95
ALZHEIMER'S DISEASE	upregulates	disease	0.95
Neurodegeneration	involved_in	process	0.90
Motor Neuron Degeneration	associated_with	phenotype	0.90
motor neuron degeneration	regulates	disease	0.90
Motor Neurons	expressed_in	cell_type	0.85
Motor Neuron Degeneration	protects_against	phenotype	0.85
ALS	associated_with	disease	0.85
Motor Neuron	expressed_in	cell_type	0.85
Alzheimer's disease	associated_with	disease	0.80
amyotrophic lateral sclerosis	upregulated_in	disease	0.80
Huntington's disease	associated_with	disease	0.80
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
Parkinson's disease	associated_with	disease	0.80
colorectal cancer	promotes	disease	0.80
Cell Survival	promotes	process	0.80
Colorectal Cancer	implicated_in	disease	0.75
Neurodegeneration	contributes_to	process	0.75
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.75
TDP-43	regulates	protein	0.70
Huntington's disease	biomarker_for	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Parkinson's disease	biomarker_for	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Aging	regulates	disease	0.65
Als	interacts_with	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Als	stabilizes	disease	0.65
Neurodegeneration	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65

Incoming (107)

Source	Relation	Type	Str
Loss Of TDP-43 Function	downregulates	mechanism	0.95
TDP-43	regulates	protein	0.95
TARDBP	regulates	protein	0.95
Nuclear TDP-43 Loss	downregulates	mechanism	0.94
Nuclear Tdp-43 Loss	downregulates	mechanism	0.90
TDP-43	binds	protein	0.80
CSF1	activates	gene	0.60
BNIP3L	activates	gene	0.60
STAT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
RELA	interacts_with	gene	0.60
TNFRSF21	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
GAS5	expressed_in	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
GAS5	activates	gene	0.60
HIF1A	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
JUN	interacts_with	gene	0.60
AGING	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ALS	activates	gene	0.60
PARKINSON	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	inhibits	gene	0.60
SOX2	interacts_with	gene	0.60
ATF2	activates	gene	0.60
TNF	activates	gene	0.60
CD163	activates	gene	0.60
DNA	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
AMPK	activates	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
GENES	activates	gene	0.60
ALS	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
MALAT1	interacts_with	gene	0.60
MALAT1	activates	gene	0.60
BECLIN1	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
GAPDH	expressed_in	gene	0.60
JAK	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
MALAT1	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H7: NEAT1 Epigenetic Rewiring Under Proteotoxic Stress	0.550	neurodegeneration	Investigate mechanisms of epigenetic rep
A-Tract Bulge Conserved Motifs Enable Selective Targeting of	0.413	molecular biology	What are the conserved secondary structu

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEAT1 in their description or question text

No additional research found