gene 1,666 words KG: ATG3
Contents

ATG3 Gene

🧬 Gene Info
Gene SymbolATG3
Full NameAutophagy Related 3
Chromosome3q13.11
Functionis an essential autophagy gene encoding a ubiquitin-like conjugating enzyme that plays a critical role in autophagosome formation[@mizushima2011].
Molecular Weight~35 kDa
Amino Acids314 amino acids
Exons12
PathwaysApoptosis, Autophagy, Car-T, Immunotherapy, Tdp-43
GeneCardsATG3
Human Protein AtlasATG3
Associated DiseasesALS, Inflammation, Ms, Osteoarthritis, Rheumatoid Arthritis
InteractionsACHE, AGING, AND, APOPTOSIS, ARAF, ATG12
KG Connections248 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ARAF Gene
gene · KG edge: activates
ATF4 Gene
gene · KG edge: regulates
ATG10 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

CAT therapeutic_target ATG3
ATG4B therapeutic_target ATG3
TARDBP therapeutic_target ATG3
ATG13 contributes_to ATG3
ATG5 contributes_to ATG3
NCOA4 activates ATG3
ATG7 contributes_to ATG3
RAB7A activates ATG3
ATG4B contributes_to ATG3
ATG3 protects_against CD19 CAR-T cell cytotoxicity

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