| Gene Symbol | ATG3 |
| Full Name | Autophagy Related 3 |
| Aliases | ATG3PROTEIN |
| Chromosome | 3q13.11 |
| Function | is an essential autophagy gene encoding a ubiquitin-like conjugating enzyme that plays a critical role in autophagosome formation[@mizushima2011]. |
| Subcellular Localization | </th><td>Cytoplasm, Cytosol</td></tr> |
| Molecular Weight | ~35 kDa |
| Amino Acids | 314 amino acids |
| Exons | 12 |
| Pathways | Apoptosis, Autophagy, Car-T, Immunotherapy, Tdp-43 |
| GeneCards | ATG3 |
| Human Protein Atlas | ATG3 |
| Active Site Cysteine | Contains a conserved catalytic cysteine residue (Cys264) that forms a thioester intermediate with ubiquitin-like LC3 |
| Ubl Domain | Contains a ubiquitin-like (Ubl) domain homologous to ubiquitin, mediating protein-protein interactions |
| Flexible N-terminal Region | Contains serine-rich regions that may regulate protein interactions |
| Associated Diseases | ALS, Inflammation, Ms, Osteoarthritis, Rheumatoid Arthritis |
| Interactions | ACHE, AGING, AND, APOPTOSIS, ARAF, ATG12 |
| KG Connections | 246 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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