gene

YY1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YY1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

219Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

YY1 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 74 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	YY1
Full Name	Yin Yang 1
Chromosome	14q32.31
Protein Type	Transcription Factor
Function	The YY1 gene encodes Yin Yang 1, a ubiquitously expressed zinc-finger transcription factor.
Primary Expression	Ubiquitous, Brain, Muscle, Heart
Pathways	Cgas-Sting, Mtor, Oxidative Phosphorylation
UniProt ID	Q08050
NCBI Gene ID	7528
Ensembl ID	ENSG00000100811
OMIM	400713
GeneCards	YY1
Human Protein Atlas	YY1
Associated Diseases	Aging, Als, Alzheimer, Ataxia, Dystonia
Interactions	AGING, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, ANG, App
KG Connections	219 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: YY1 — AlphaFold Q08050 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

YY1 — Yin Yang 1

gene · 622 words

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Pathway Diagram

graph TD
    YY1["YY1"]
    Cardiac{"Cardiac"}
    YY1 -->|"expressed in"| Cardiac
    Ms{"Ms"}
    YY1 -->|"expressed in"| Ms
    Autism{"Autism"}
    YY1 -->|"expressed in"| Autism
    Cancer{"Cancer"}
    YY1 -->|"activates"| Cancer
    YY1 -->|"therapeutic target"| Ms
    YY1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    YY1 -->|"therapeutic target"| Tumor
    Alzheimer{"Alzheimer"}
    YY1 -->|"regulates"| Alzheimer
    YY1 -->|"interacts with"| Ms
    YY1 -->|"regulates"| Ms
    Diabetes{"Diabetes"}
    YY1 -->|"regulates"| Diabetes
    YY1 -->|"regulates"| Cardiac
    CANCER["CANCER"]
    CANCER -->|"activates"| YY1
    LC3B["LC3B"]
    LC3B -->|"activates"| YY1
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"therapeutic target"| YY1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"therapeutic target"| YY1
    TREM2["TREM2"]
    TREM2 -->|"expressed in"| YY1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"inhibits"| YY1
    GPX4["GPX4"]
    GPX4 -->|"inhibits"| YY1
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"regulates"| YY1
    RAB7A["RAB7A"]
    RAB7A -->|"regulates"| YY1
    MICROGLIA -->|"inhibits"| YY1
    style YY1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (124)

Target	Relation	Type	Str
SLC1A2	downregulates	gene	0.95
LCN2	regulates	gene	0.90
ubiquitin-proteasome	participates_in	pathway	0.70
Als	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Aging	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	regulates	disease	0.65
Ataxia	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Huntington	associated_with	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	interacts_with	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Autoimmune	activates	disease	0.65
Parkinson	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Senescence	regulates	disease	0.65
B Cell	activates	cell_type	0.60
Raf	regulates	protein	0.60
Ras	regulates	protein	0.60
App	activates	protein	0.60
HDAC2	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60

Incoming (95)

Source	Relation	Type	Str
STING	binds_to	protein	0.90
RELA	activates	gene	0.90
STING	inhibits	protein	0.88
HUNTINGTON'S DISEASE	associated_with	gene	0.60
AGING	activates	gene	0.60
GENES	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
EAAT2	activates	gene	0.60
IKK	activates	gene	0.60
AND	regulates	gene	0.60
SIRT1	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
ADNP	associated_with	gene	0.60
HDAC2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PPARG	encodes	gene	0.60
TFEB	regulates	gene	0.60
ASTROCYTES	causes	gene	0.60
GENES	expressed_in	gene	0.60
TFEB	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
SIRT6	regulates	gene	0.60
ATG	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
PARKINSON	activates	gene	0.60
NF-ΚB	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
LCN2	associated_with	gene	0.60
LCN2	regulates	gene	0.60
TREM2	expressed_in	gene	0.60
RAB7A	regulates	gene	0.60
STAT3	activates	gene	0.60
CCL5	activates	gene	0.60
IDO1	activates	gene	0.60
EGFR	activates	gene	0.60
GAIN	regulates	gene	0.60
MTOR	regulates	gene	0.60
TNF	activates	gene	0.60
MRPL12	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YY1 in their description or question text

No additional research found