concept

IL8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

194Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IL8 is a concept in neurodegeneration research. Key relationships include: expressed in, activates, therapeutic target. Associated with Als, Breast Cancer, Cancer. Connected to 102 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IL8
Key Genes/Proteins	ABCB1, ABCG2, ACTB, AKT, AKT1, ALZHEIMER
Related Diseases	Als, Alzheimer
Related Pathways	Akt, Angiogenesis

Pathway Diagram

graph TD
    IL8["IL8"]
    IL8 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL8 -->|"expressed in"| Als["Als"]
    IL8 -->|"activates"| Epilepsy["Epilepsy"]
    IL8 -->|"activates"| Ms["Ms"]
    IL8 -->|"expressed in"| Innate_Immunity["Innate Immunity"]
    IL8 -->|"expressed in"| Toll_Like_Receptor["Toll-Like Receptor"]
    IL8 -->|"expressed in"| Immune_Response["Immune Response"]
    IL8 -->|"expressed in"| DICER1["DICER1"]
    IL8 -->|"expressed in"| NR3C1["NR3C1"]
    IL8 -->|"expressed in"| IL1B["IL1B"]
    hyperoxia["hyperoxia"] -->|"contributes to"| IL8
    TNF["TNF"] -->|"activates"| IL8
    NFKB1["NFKB1"] -->|"activates"| IL8
    TPM2["TPM2"] -->|"regulates"| IL8
    NFKB["NFKB"] -->|"regulates"| IL8
    DUPILUMAB["DUPILUMAB"] -->|"inhibits"| IL8
    GAL["GAL"] -->|"activates"| IL8
    CYTOKINES["CYTOKINES"] -->|"expressed in"| IL8
    TLR2["TLR2"] -->|"expressed in"| IL8
    OCLN["OCLN"] -->|"expressed in"| IL8

Outgoing (103)

Target	Relation	Type	Str
Immune Aging	modulates	process	0.85
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.85
Tumor	therapeutic_target	disease	0.75
INFLAMMATION	activates	phenotype	0.72
muscle wasting	associated_with	phenotype	0.70
Breast Cancer	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Obesity	inhibits	disease	0.65
Cancer	activates	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Epilepsy	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
NDEL1	expressed_in	gene	0.60
DNA	activates	gene	0.60
CCL2	associated_with	gene	0.60
GCH1	expressed_in	gene	0.60
CCL5	associated_with	gene	0.60
CANCER	activates	gene	0.60
NR3C1	expressed_in	gene	0.60
TNF	activates	gene	0.60
ROS	activates	gene	0.60
DISC1	expressed_in	gene	0.60
CXCL1	associated_with	gene	0.60
VEGFA	therapeutic_target	gene	0.60
CXCL8	associated_with	gene	0.60
BDNF	expressed_in	gene	0.60
DICER1	expressed_in	gene	0.60
ANG	associated_with	gene	0.60
TNFA	therapeutic_target	gene	0.60
TNF-Α	activates	gene	0.60
IL-6	expressed_in	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
Angiogenesis	activates	pathway	0.60
CANCER	therapeutic_target	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
JAK1	therapeutic_target	gene	0.60
CXCL8	therapeutic_target	gene	0.60
Nf-Kb	activates	pathway	0.60

Incoming (91)

Source	Relation	Type	Str
hyperoxia	contributes_to	phenotype	0.90
TNF	activates	protein	0.90
NFKB	upregulates	protein	0.90
TPM2	regulates	gene	0.80
NFKB1	activates	gene	0.80
DUPILUMAB	inhibits	drug	0.72
NFKB	regulates	protein	0.72
CCL3	activates	gene	0.60
CCL5	activates	gene	0.60
CCL2	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
CCL2	activates	gene	0.60
TLR4	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
IRAK2	activates	gene	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
IKBKG	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60
HMGB1	expressed_in	gene	0.60
IKBKB	activates	gene	0.60
BCL2L1	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CLDN5	activates	gene	0.60
IL6	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
IL6	therapeutic_target	gene	0.60
FGF21	activates	gene	0.60
ABCB1	activates	gene	0.60
ABCG2	activates	gene	0.60
FOS	inhibits	gene	0.60
FOSB	inhibits	gene	0.60
CYTOKINES	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
OCLN	expressed_in	gene	0.60
ZO1	expressed_in	gene	0.60
CLDN5	expressed_in	gene	0.60
CXCL8	regulates	gene	0.60
IL6	regulates	gene	0.60
RAB7A	regulates	gene	0.60
IL1B	regulates	gene	0.60
CD8	regulates	gene	0.60
EGFR	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL8 in their description or question text

No additional research found