gene

HBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

37Outgoing

11Incoming

0Experiments

0Debates

Summary

HBB is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in, expressed in. Associated with Als, Inflammation, Sickle Cell. Connected to 17 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	HBB
Full Name	Hemoglobin Subunit Beta
Chromosome	11p15.5
Function	encodes the beta-globin chain of hemoglobin, which pairs with alpha-globin to form the functional hemoglobin tetramer
Primary Expression	dopaminergic neurons of substantia nigra - May protect against oxidative stress - Expression altered with disease progression - Possible interaction w
UniProt ID	P68871
NCBI Gene ID	3043
Ensembl ID	ENSG00000244734
GeneCards	HBB
Human Protein Atlas	HBB
Associated Diseases	Sickle Cell
Interactions	AND, ARG1, CHI3L1, ERBB2, GENES, HBA1
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HBB — AlphaFold P68871 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HBB Gene

gene · 945 words

→

Pathway Diagram

graph TD
    HBB["HBB"]
    neurodegeneration{"neurodegeneration"}
    HBB -->|"implicated_in"| neurodegeneration
    BCL2L1["BCL2L1"]
    HBB -->|"expressed_in"| BCL2L1
    TNF["TNF"]
    HBB -->|"biomarker_for"| TNF
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    HBB -->|"biomarker_for"| OXIDATIVE_STRESS
    BDNF["BDNF"]
    HBB -->|"biomarker_for"| BDNF
    CYTOKINES["CYTOKINES"]
    HBB -->|"biomarker_for"| CYTOKINES
    IL_6["IL-6"]
    HBB -->|"biomarker_for"| IL_6
    INFLAMMATION["INFLAMMATION"]
    HBB -->|"biomarker_for"| INFLAMMATION
    TNF__["TNF-Alpha"]
    HBB -->|"biomarker_for"| TNF__
    HO_1["HO-1"]
    HBB -->|"biomarker_for"| HO_1
    CXCL10["CXCL10"]
    HBB -->|"biomarker_for"| CXCL10
    ANG["ANG"]
    HBB -->|"biomarker_for"| ANG
    VEGFA["VEGFA"]
    HBB -->|"biomarker_for"| VEGFA
    Sickle_Cell(["Sickle Cell"])
    HBB -->|"causes"| Sickle_Cell
    Als{"Als"}
    HBB -->|"biomarker_for"| Als
    Inflammation{"Inflammation"}
    HBB -->|"biomarker_for"| Inflammation
    Oxidative_Stress["Oxidative Stress"]
    HBB -->|"biomarker_for"| Oxidative_Stress
    style HBB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (37)

Target	Relation	Type	Str
Iron Metabolism	involved_in	process	0.95
Als	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Sickle Cell	causes	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	inhibits	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
IL-18	expressed_in	gene	0.60
ERBB2	activates	gene	0.60
PD-L1	activates	gene	0.60
Neutrophil	activates	cell_type	0.60
Interferon	activates	protein	0.60
IL-17	activates	gene	0.60
RNA	biomarker_for	gene	0.60
MME	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
Hemoglobin	inhibits	protein	0.60
HBA1	activates	gene	0.60
Hemoglobin	activates	protein	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
BCL2L1	expressed_in	gene	0.60
IL-6	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
TNF-Α	biomarker_for	gene	0.60
HO-1	biomarker_for	gene	0.60
Oxidative Stress	biomarker_for	pathway	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
CXCL10	biomarker_for	gene	0.60
ANG	biomarker_for	gene	0.60
VEGFA	biomarker_for	gene	0.60

Incoming (11)

Source	Relation	Type	Str
SORL1	associated_with	gene	0.60
MME	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ARG1	activates	gene	0.60
CHI3L1	activates	gene	0.60
MMP9	activates	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
RNA	inhibits	gene	0.60
IL-10	activates	gene	0.60
LCN2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity