concept

PD-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PD-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PD-1
Key Genes/Proteins	ANGPT1, APOB, APOPTOSIS, App, ATM, BCL2L1
Related Diseases	Als, ALS, brain metastases, Cancer, Carcinoma
Related Pathways	Adaptive Immunity, Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

mechanism · 3120 words

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Pathway Diagram

graph TD
    PD_1["PD-1"]
    style PD_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PD_1 -.->|"inhibits"| PD_L1([PD-L1])
    PD_1 -->|"activates"| Mitophagy["Mitophagy"]
    PD_1 -.->|"downregulates"| BCL2L1([BCL2L1])
    PD_1 -.->|"inhibits"| T_Cell_Activation["T Cell Activation"]
    PD_1 -.->|"inhibits"| CT_26_Tumor["CT-26 Tumor"]
    PD_1 -.->|"inhibits"| Cancer["Cancer"]
    PD_1 -.->|"inhibits"| ALS["ALS"]
    PD_1 -.->|"inhibits"| Carcinoma["Carcinoma"]
    PD_1 -->|"activates"| Tumor["Tumor"]
    LKB1([LKB1]) -->|"regulates"| PD_1
    PD_L1 -->|"binds"| PD_1
    Nivolumab{"Nivolumab"} -->|"targets"| PD_1
    Pembrolizumab{"Pembrolizumab"} -->|"targets"| PD_1
    NFAT([NFAT]) -->|"upregulates"| PD_1
    WNT([WNT]) -.->|"inhibits"| PD_1
    LZTR1([LZTR1]) -.->|"inhibits"| PD_1
    SF3B1([SF3B1]) -.->|"inhibits"| PD_1
    APOB([APOB]) -.->|"inhibits"| PD_1

Outgoing (148)

Target	Relation	Type	Str
PD-L1	inhibits	gene	0.95
T cell exhaustion	promotes	process	0.90
Mitophagy	activates	process	0.85
BCL2L1	downregulates	gene	0.82
T Cell Activation	inhibits	process	0.70
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Ferroptosis	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
PD-L1	activates	gene	0.65
Glioblastoma	activates	disease	0.65
Obesity	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Adaptive Immunity	activates	pathway	0.60
Egfr	inhibits	protein	0.60
Vegfr	inhibits	protein	0.60
Interferon	activates	protein	0.60
Cytokine	inhibits	protein	0.60
OMA1	regulates	gene	0.60
Cgas-Sting	activates	pathway	0.60
Insulin	regulates	protein	0.60
INSULIN RESISTANCE	regulates	gene	0.60
Interferon Signaling	activates	pathway	0.60
Vegf	inhibits	protein	0.60
Pdgf	activates	protein	0.60
Rb	activates	protein	0.60
RELA	therapeutic_target	gene	0.60
CTLA4	associated_with	gene	0.60
Dna Methylation	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
VEGFA	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
MET	inhibits	gene	0.60
T Cell	inhibits	cell_type	0.60
Cholesterol	activates	pathway	0.60
Epithelial	activates	cell_type	0.60

Incoming (106)

Source	Relation	Type	Str
LKB1	regulates	gene	0.95
NFAT	upregulates	protein	0.88
brain metastases	associated_with	disease	0.70
PIK3CA	expressed_in	gene	0.60
PD-L1	associated_with	gene	0.60
RB1	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
PTEN	expressed_in	gene	0.60
PRDM1	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
GBM	regulates	gene	0.60
OMA1	regulates	gene	0.60
HSPA9	activates	gene	0.60
DNA	activates	gene	0.60
CGAS-STING	activates	gene	0.60
LKB1	expressed_in	gene	0.60
CDKN2A	expressed_in	gene	0.60
MAP2K2	expressed_in	gene	0.60
ATM	expressed_in	gene	0.60
FOXP3	associated_with	gene	0.60
TP53	expressed_in	gene	0.60
TCR	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
VIRAL INFECTIONS	inhibits	gene	0.60
DLL4	activates	gene	0.60
EGFR	activates	gene	0.60
RNA	activates	gene	0.60
NOTCH	therapeutic_target	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
TRIM34	associated_with	gene	0.60
CGAS	activates	gene	0.60
INSULIN RESISTANCE	regulates	gene	0.60
CCL2	activates	gene	0.60
NOTCH2	activates	gene	0.60
EOMES	activates	gene	0.60
TP53	activates	gene	0.60
GENES	activates	gene	0.60
RYR2	activates	gene	0.60
PD-L1	interacts_with	gene	0.60
TCR	activates	gene	0.60
CD4	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
GSH	activates	gene	0.60
CD38	associated_with	gene	0.60
PD-L1	activates	gene	0.60
CD8	inhibits	gene	0.60
MAF	inhibits	gene	0.60
CD4	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PD-1 in their description or question text

No additional research found