Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| h-3cdc8defe3 | targeted_by | hypothesis | 1.00 |
| PD-1 | upregulates | protein | 0.88 |
| ANO6 | regulates | gene | 0.70 |
| ANO6 expression | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-3cdc8defe3 | targets | hypothesis | 1.00 |
| PLCG2 | activates | protein | 0.70 |
| calcineurin | regulates | protein | 0.70 |
| calcineurin | activates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alany | 0.550 | neurodegeneration | How does gut microbiome dysbiosis contri |
| P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to S | 0.423 | neurodegeneration | How do perivascular cells specifically r |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning NFAT in their description or question text
No additional research found