gene

CCR8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

50Outgoing

6Incoming

0Experiments

0Debates

Summary

Comprehensive information about CCR8 (C-C Chemokine Receptor Type 8), a G protein-coupled receptor involved in immune cell trafficking and neuroinflammation.

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🧬 Gene Info

Gene Symbol	CCR8
Full Name	C-C Chemokine Receptor Type 8
Chromosome	3p22.2
Protein Type	Receptor
Function	is a seven-transmembrane receptor that
Molecular Weight	40 kDa
Amino Acids	355 aa
Exons	2
Pathways	MAPK, PI3K pathway
UniProt ID	[P41597](https://www.uniprot.org/uniprot/P41597)
Ensembl ID	ENSG00000179934
GeneCards	CCR8
Human Protein Atlas	CCR8
Chromosomal location	3p22.2
Genomic size	~2.5 kb coding region
Associated Diseases	Cancer
Interactions	CCL2, CCL5, CCR3, CD4, CYTOKINES, FOXP3
KG Connections	62 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CCR8 Gene

gene · 2904 words

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Pathway Diagram

graph TD
    CCR8["CCR8"]
    Asthma{"Asthma"}
    CCR8 -->|"interacts_with"| Asthma
    Inflammation{"Inflammation"}
    CCR8 -->|"interacts_with"| Inflammation
    Als{"Als"}
    CCR8 -->|"regulates"| Als
    Cancer{"Cancer"}
    CCR8 -.->|"inhibits"| Cancer
    Atherosclerosis{"Atherosclerosis"}
    CCR8 -.->|"inhibits"| Atherosclerosis
    GRN(["GRN"])
    GRN -->|"activates"| CCR8
    PGRN(["PGRN"])
    PGRN -->|"activates"| CCR8
    TNFR2(["TNFR2"])
    TNFR2 -.->|"inhibits"| CCR8
    CCL3(["CCL3"])
    CCL3 -->|"expressed_in"| CCR8
    style CCR8 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (56)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.65
Inflammation	interacts_with	disease	0.65
Asthma	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Dendritic Cell	inhibits	cell_type	0.60
COMPLEMENT	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
PD-L1	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Epithelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Akt	associated_with	protein	0.60
Ras	associated_with	protein	0.60
Pi3K	associated_with	protein	0.60
PD-1	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Immune Response	activates	pathway	0.60
MIRNAS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
ADCY2	regulates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
CCL2	interacts_with	gene	0.60
T Cell	regulates	cell_type	0.60
T Cell	activates	cell_type	0.60
Stem Cell	activates	cell_type	0.60
Nf-Κb	activates	pathway	0.60
T Cell	inhibits	cell_type	0.60
CYTOKINES	interacts_with	gene	0.60
Ras	expressed_in	protein	0.60
CYTOKINES	expressed_in	gene	0.60
App	expressed_in	protein	0.60
CCR3	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
PROGRANULIN	transports	gene	0.60
FOXP3	activates	gene	0.60
CD4	associated_with	gene	0.60
LAG3	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
CD163	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
PGRN	activates	gene	0.60
GRN	activates	gene	0.60
TNFR2	inhibits	gene	0.60
CCL3	expressed_in	gene	0.60
MS4A4A	associated_with	gene	0.60
GRM1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCR8 in their description or question text

No additional research found